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ChemicalBook >> CAS DataBase List >>Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy-

Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy-

Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy- Structure
Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy- structure
CAS No.
2361659-61-0
Chemical Name:
Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy-
Synonyms
AES-135, 10 mM in DMSO;AES135,HDAC,HDAC3,HDAC11,pancreatic,HDAC6,anti-tumor,Inhibitor,AES 135,Histone deacetylases,inhibit,AES-135;Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy-
CBNumber:
CB85563085
Molecular Formula:
C33H29F6N3O5S
Molecular Weight:
693.66
MDL Number:
MFCD31813798
MOL File:
2361659-61-0.mol
Last updated:2025-12-10 09:00:29
Product description Number Pack Size Price
AES-135 98.31% CS-0086984 5mg $400
AES-135 98.31% CS-0086984 10mg $680
AES-135 98.31% CS-0086984 25mg $1350
AES-135 98.31% CS-0086984 50mg $2200
AES-135 98.31% CS-0086984 100mg $3400
Request For Quotation

Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy- Properties

storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (144.16 mM; Need ultrasonic)
form Solid
color White to off-white

Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0086984 AES-135 98.31% 2361659-61-0 5mg $400 2021-12-16 Buy
ChemScene CS-0086984 AES-135 98.31% 2361659-61-0 10mg $680 2021-12-16 Buy
ChemScene CS-0086984 AES-135 98.31% 2361659-61-0 25mg $1350 2021-12-16 Buy
ChemScene CS-0086984 AES-135 98.31% 2361659-61-0 50mg $2200 2021-12-16 Buy
ChemScene CS-0086984 AES-135 98.31% 2361659-61-0 100mg $3400 2021-12-16 Buy
Product number Packaging Price Buy
CS-0086984 5mg $400 Buy
CS-0086984 10mg $680 Buy
CS-0086984 25mg $1350 Buy
CS-0086984 50mg $2200 Buy
CS-0086984 100mg $3400 Buy

Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy- Chemical Properties,Uses,Production

Uses

AES-135, a hydroxamic acid-based pan-HDAC inhibitor, prolongs survival in an orthotopic mouse model of pancreatic cancer. AES-135 inhibits HDAC3, HDAC6, HDAC8, and HDAC11 with IC50s ranging from 190-1100 nM[1].

in vivo

AES-135 (50 mg/kg; intraperitoneal injection; 5 days a week; for 1 month) treatment significantly increases survival of C57Bl/6 mice implanted with KPC2 cells[1].
NSG mice are dosed with a single 20 mg/kg intraperitoneal (IP) injection, and blood is taken at 0.5 h, 1 h, 2 h, 4 h, 8 h, and 24 h. AES-135 achieved μM concentrations in the blood, reaching Cmax 7452 ng/mL (10.74 μM) within 30 min, which is sustained for 8 h. The blood concentration of AES-135 is dose dependent, achieving an average of 323 ng/mL (0.47 μM) with 10 mg/kg dosing and 1829 ng/mL (2.64 μM) with 40 mg/kg. AES-135 shows an impressive pharmacokinetic profile in mice with an in vivo half-life of 5.0 h[1].

Animal Model:C57Bl/6 mice injected with KPC2 cells[1]
Dosage:50 mg/kg
Administration:Intraperitoneal injection; 5 days a week; for 1 month
Result:Significantly increased survival of mice.

IC 50

HDAC6: 190 nM (IC50); HDAC11: 636 nM (IC50); HDAC3: 654 nM (IC50); HDAC8: 1100 nM (IC50)

References

[1] Shouksmith AE, et al. Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer. J Med Chem. 2019 Mar 14;62(5):2651-2665. DOI:10.1021/acs.jmedchem.8b01957

Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy- Suppliers

Global( 20)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39035 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19961 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2391 55
Hangzhou ChangCun Biotechnology Co., Ltd. 0571-; 13567100326 158848739@qq.com China 108 50
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
Chengdu Peter-like Biotechnology Co., Ltd. 18108052721 2850505130@qq.com China 5167 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223; psaitong@jm-bio.com China 29757 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
TargetMol Chemicals Inc. 		58
BOC Sciences 65
Shanghai Beckham Medical Technology Co., Ltd 55
Hangzhou ChangCun Biotechnology Co., Ltd. 50
Fan De(Beijing) Biotechnology Co., Ltd. 58
Chengdu Peter-like Biotechnology Co., Ltd. 58
Beijing Jin Ming Biotechnology Co., Ltd. 58

View Lastest Price from Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AES-135 pictures 2025-12-09 AES-135
2361659-61-0
 US $76.00-278.00 / mg 98.01% 10g TargetMol Chemicals Inc.
AES-135 pictures 2025-12-09 AES-135
2361659-61-0
 US $76.00-278.00 / mg 98.01% 10g TargetMol Chemicals Inc.
AES-135 pictures 2025-05-17 AES-135
2361659-61-0
 US $76.00-278.00 / mg 98.01% 10g TargetMol Chemicals Inc.
  • AES-135 pictures
  • AES-135
    2361659-61-0
  • US $76.00-278.00 / mg
  • 98.01%
  • TargetMol Chemicals Inc.
  • AES-135 pictures
  • AES-135
    2361659-61-0
  • US $76.00-278.00 / mg
  • 98.01%
  • TargetMol Chemicals Inc.
  • AES-135 pictures
  • AES-135
    2361659-61-0
  • US $76.00-278.00 / mg
  • 98.01%
  • TargetMol Chemicals Inc.

Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy- Spectrum

Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy-(2361659-61-0)1HNMR
Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy- AES135,HDAC,HDAC3,HDAC11,pancreatic,HDAC6,anti-tumor,Inhibitor,AES 135,Histone deacetylases,inhibit,AES-135 AES-135, 10 mM in DMSO 2361659-61-0 C33H29F6N3O5S