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1-Tetradecanol

Description References
1-Tetradecanol
1-Tetradecanol structure
CAS No.
112-72-1
Chemical Name:
1-Tetradecanol
Synonyms
Epal 14;alfol14;lanettek;loxanolv;myristic;myristyl;Alfol 14;Loxanol V;Lorol C14;dytolr-52
CBNumber:
CB8689436
Molecular Formula:
C14H30O
Formula Weight:
214.39
MOL File:
112-72-1.mol

1-Tetradecanol Properties

Melting point:
35-39 °C(lit.)
Boiling point:
289 °C(lit.)
Density 
0.823 g/mL at 25 °C(lit.)
vapor density 
7.4 (vs air)
vapor pressure 
<1 hPa (20 °C)
refractive index 
1.4454
Flash point:
>230 °F
storage temp. 
−20°C
solubility 
water: soluble0.00013g/L at 23°C
form 
Low Melting Solid, Crystalline Powder, Crystals, Flakes, Pellets and/or Chunks
Specific Gravity
0.823
color 
White
Water Solubility 
insoluble
Merck 
14,6335
BRN 
1742652
CAS DataBase Reference
112-72-1(CAS DataBase Reference)
NIST Chemistry Reference
1-Tetradecanol(112-72-1)
EPA Substance Registry System
1-Tetradecanol(112-72-1)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H315-H319-H410
Precautionary statements  P305+P351+P338-P273-P501-P264-P280a-P321-P332+P313-P337+P313
Hazard Codes  Xi
Risk Statements  38-36
Safety Statements  24/25-26
RIDADR  UN 3077 9 / PGIII
WGK Germany  -
RTECS  XB8655000
9
Autoignition Temperature 489 °F
TSCA  Yes
HSCode  2905 19 00
HazardClass  9
PackingGroup  III
Toxicity LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 2000 mg/kg

NFPA 704

Diamond Hazard Value Description
1
0
Health  
Flammability   1 Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
Instability   0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
Special  

(NFPA, 2010)

1-Tetradecanol price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 185388 1-Tetradecanol 97% 112-72-1 100g $52.8 2018-11-13 Buy
Sigma-Aldrich 87158 1-Tetradecanol Selectophore , ≥99.0% 112-72-1 1g $71.6 2018-11-13 Buy
TCI Chemical T0084 1-Tetradecanol >98.0%(GC) 112-72-1 25mL $11 2018-11-22 Buy
TCI Chemical T0084 1-Tetradecanol >98.0%(GC) 112-72-1 500mL $33 2018-11-22 Buy
Alfa Aesar A19638 1-Tetradecanol, 97+% 112-72-1 100g $20.8 2018-11-13 Buy

1-Tetradecanol Chemical Properties,Uses,Production

Description

1-Tetradecanol is a kind of straight-chain saturated fatty alcohol. It is often used as an ingredient in cosmetics such as cold creams because of its emollient properties. It can also be used as the intermediate during the manufacturing of some organic compounds like surfactants. Some studies have shown that it can inhibit the endothelial activation and reduce tissue responsiveness to cytokines, having the potential to treat the periodontitis based on studies on rabbits. It is also employed for the fabrication of temperature-regulated drug release system based on phase-change materials.

References

Lehmler, Hans-Joachim, and Paul M. Bummer. "Behavior of 10-(perfluorohexyl)-decanol, a partially fluorinated analog of hexadecanol, at the air–water interface." Journal of fluorine chemistry 117.1 (2002): 17-22.
Hasturk, Hatice, et al. "1-Tetradecanol complex reduces progression of porphyromonas gingivalis–induced experimental periodontitis in rabbits." Journal of periodontology 78.5 (2007): 924-932.
Hasturk, H, et al. "1-Tetradecanol complex: therapeutic actions in experimental periodontitis." Journal of Periodontology 80.7(2009): 1103-13.
Choi, Sung-Wook, Yu Zhang, and Younan Xia. "A temperature-sensitive drug release system based on phase-change materials." Angewandte Chemie International Edition 49.43 (2010): 7904-7908.

Chemical Properties

Myristyl alcohol occurs as a white crystalline solid with a waxy odor. Also reported as opaque leaflets or crystals from ethanol.

Chemical Properties

white low melting solid or flakes

Uses

As emollient for cold creams, etc., also for making the sulfated alcohol whose sodium salt is applicable as a "wetter" in textiles.

Uses

myristyl alcohol is an emollient often used in hand creams, cold creams, and lotions to give them a smooth, velvety feel. Sources indicate it as being mildly comedogenic and potentially irritating.

Production Methods

Myristyl alcohol is found in spermaceti wax and sperm oil, and may be synthesized by sodium reduction of fatty acid esters or the reduction of fatty acids by lithium aluminum hydride. It can also be formed from acetaldehyde and dimethylamine.

Definition

ChEBI: A long-chain fatty alcohol that is tetradecane in which one of the terminal methyl hydrogens is replaced by a hydroxy group

General Description

Colorless thick liquid (heated) with a faint alcohol odor. Solidifies and floats on water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

1-Tetradecanol is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Health Hazard

Low toxicity. Overexposure causes some central nervous system depression. Prolonged skin contact causes skin irritation.

Pharmaceutical Applications

Myristyl alcohol is used in oral, parenteral, and topical pharmaceutical formulations. It has been evaluated as a penetration enhancer in melatonin transdermal patches in rats.
Myristyl alcohol has also been tested as a bilayer stabilizer in niosome formulations containing ketorolac tromethamine,and zidovudine.Niosomes containing myristyl alcohol showed a considerably slower release rate of ketorolac tromethamine than those containing cholesterol.This was also observed with the zidovudine formulation.

Safety

Myristyl alcohol is used in oral parenteral, and topical pharmaceutical formulations. The pure form of myristyl alcohol is mildly toxic by ingestion and may be carcinogenic; experimental tumorigenic data are available.It is also a human skin irritant. In animal studies of the skin permeation enhancement effect of saturated fatty alcohols, myristyl alcohol exhibited a lower effect when compared with decanol, undecanol, or lauryl alcohol but caused greater skin irritation.A study investigating contact sensitization to myristyl alcohol revealed that patch testing of myristyl alcohol 10% petrolatum should not be carried out owing to observed irritant effects; thus the use of a lower concentration of myristyl alcohol for such tests (5% petrolatum) was recommended.Myristyl alcohol has been associated with some reports of contact allergy.(8,9)A moderate-to-severe erythema and moderate edema are seen when 75 mg is applied to human skin intermittently in three doses over 72 hours.
LD50(rabbit, skin): 7.1 g/kg
LD50(rat, oral): 33.0 g/kg

storage

The bulk material should be stored in a well-closed container in a cool, dry place.

Purification Methods

Crystallise the alcohol from aqueous EtOH. It has also been purified by zone melting. [Beilstein 1 IV 1864.]

Incompatibilities

Myristyl alcohol is combustible when exposed to heat or flame. It can react with oxidizing materials. When heated to decomposition, it emits acrid smoke and irritating fumes.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral tablet: sustained-release; and topical formulations: cream, lotion, suspension). Included in nonparenteral (topical cream) formulations licensed in the UK.

1-Tetradecanol Preparation Products And Raw materials

Raw materials

Preparation Products


1-Tetradecanol Suppliers

Global( 204)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21668 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8921 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
breeduan@crovellbio.com CHINA 2314 58

View Lastest Price from 1-Tetradecanol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-16 1-Tetradecanol
112-72-1
US $1.00 / KG 1KG 98% 500kg career henan chemical co

1-Tetradecanol Spectrum


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