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Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)-

Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)- structure

CAS No.: 941521-45-5

Chemical Name:: Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)-

Synonyms: BAZ1A-IN-1;1-(3-Nitrophenyl)-3-(4-phenylthiazol-2-yl)urea;Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)-;leukemia,breast cancer,Epigenetic Reader Domain,BAZ1A IN 1,cancer,ZR-75–30,BAZ1A,BAZ1AIN1,THP-10,bromodomain-containing,lung cancer,H1975,inhibit,BAZ-1A-IN-1,BT474,Inhibitor

CBNumber:: CB89968521

Molecular Formula:: C16H12N4O3S

Molecular Weight:: 340.36

MDL Number:

MOL File:: 941521-45-5.mol

Last updated:2024-07-02 08:55:39

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Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)- Properties

Density	1.481±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 83.33 mg/mL (244.83 mM; Need ultrasonic)
form	Solid
pka	5.83±0.70(Predicted)
color	Light yellow to yellow

Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)- Chemical Properties,Uses,Production

Biological Activity

BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A[1]. BAZ1A-IN-1 (Cpd-2) (0.015-100 μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively[1].

References

[1]. Yang Z, et al. Discovery of BAZ1A bromodomain inhibitors with the aid of virtual screening and activity evaluation. Bioorg Med Chem Lett. 2021;33:127745.

Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)- Suppliers

Global( 16)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32836	60
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
ATK CHEMICAL COMPANY LIMITED	3429815786 13301662590	sales@atkchemical.com	China	9994	55
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	4182	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8014	62
Shandong Jirun Biomedical Technology Co., Ltd.	0539-0539-8613587 17661611089	2639273505@qq.com	China	165	58
Jinan Jiuli Biotechnology Co. , Ltd.	15865264761	486064515@qq.com	China	3223	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	62163	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
ATK CHEMICAL COMPANY LIMITED	55
Tianjin Kailiqi Biotechnology Co., Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Shandong Jirun Biomedical Technology Co., Ltd.	58
Jinan Jiuli Biotechnology Co. , Ltd.	58
Bide Pharmatech Ltd.	58

Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)- BAZ1A-IN-1 leukemia,breast cancer,Epigenetic Reader Domain,BAZ1A IN 1,cancer,ZR-75–30,BAZ1A,BAZ1AIN1,THP-10,bromodomain-containing,lung cancer,H1975,inhibit,BAZ-1A-IN-1,BT474,Inhibitor 1-(3-Nitrophenyl)-3-(4-phenylthiazol-2-yl)urea 941521-45-5