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ChemicalBook >> CAS DataBase List >>3-Pyrrolidinone, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[5-methoxy-2-nitro-4-[[tris(1-methylethyl)silyl]oxy]benzoyl]-, (5S)-

3-Pyrrolidinone, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[5-methoxy-2-nitro-4-[[tris(1-methylethyl)silyl]oxy]benzoyl]-, (5S)-

3-Pyrrolidinone, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[5-methoxy-2-nitro-4-[[tris(1-methylethyl)silyl]oxy]benzoyl]-, (5S)- Structure
3-Pyrrolidinone, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[5-methoxy-2-nitro-4-[[tris(1-methylethyl)silyl]oxy]benzoyl]-, (5S)- structure
CAS No.
1430738-05-8
Chemical Name:
3-Pyrrolidinone, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[5-methoxy-2-nitro-4-[[tris(1-methylethyl)silyl]oxy]benzoyl]-, (5S)-
Synonyms
Tesirine intermediate-1;(S)-5-(((tert-Butyldimethylsilyl)oxy)methyl)-1-(5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)benzoyl)pyrrolidin-3-one;3-Pyrrolidinone, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[5-methoxy-2-nitro-4-[[tris(1-methylethyl)silyl]oxy]benzoyl]-, (5S)-
CBNumber:
CB910696229
Molecular Formula:
C28H48N2O7Si2
Molecular Weight:
580.86
MDL Number:
MOL File:
1430738-05-8.mol
Last updated:2025-04-18 09:52:59
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3-Pyrrolidinone, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[5-methoxy-2-nitro-4-[[tris(1-methylethyl)silyl]oxy]benzoyl]-, (5S)- Properties

Boiling point 609.2±55.0 °C(Predicted)
Density 1.067±0.06 g/cm3(Predicted)
pka -3.28±0.40(Predicted)
form Solid
color White to off-white

3-Pyrrolidinone, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[5-methoxy-2-nitro-4-[[tris(1-methylethyl)silyl]oxy]benzoyl]-, (5S)- Chemical Properties,Uses,Production

Uses

Tesirine intermediate-1 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.

References

[1] Howard, et al. Process for the preparation of intermediates useful for the synthesis of pyrrolobenzodiazepine dimers. World Intellectual Property Organization, WO2013053872 A1. 2013-04-18.
[2] Tiberghien AC, et al. Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload. ACS Med Chem Lett. 2016;7(11):983-987. Published 2016 May 24. DOI:10.1021/acsmedchemlett.6b00062

3-Pyrrolidinone, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[5-methoxy-2-nitro-4-[[tris(1-methylethyl)silyl]oxy]benzoyl]-, (5S)- Preparation Products And Raw materials

Raw materials

Preparation Products

3-Pyrrolidinone, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[5-methoxy-2-nitro-4-[[tris(1-methylethyl)silyl]oxy]benzoyl]-, (5S)- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Haohong Pharmaceutical Co., Ltd. 400-8210725 4008210725 malulu@leyan.com China 55000 58
MoleArk Biotech 18815611055 805482182@qq.com China 199 58
Afflon Pharmaceutical (Sichuan) Co., Ltd. 17336178085 1684779048@qq.com China 1728 58
Supplier Advantage
Shanghai Haohong Pharmaceutical Co., Ltd. 58
MoleArk Biotech 58
Afflon Pharmaceutical (Sichuan) Co., Ltd. 58
3-Pyrrolidinone, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[5-methoxy-2-nitro-4-[[tris(1-methylethyl)silyl]oxy]benzoyl]-, (5S)- (S)-5-(((tert-Butyldimethylsilyl)oxy)methyl)-1-(5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)benzoyl)pyrrolidin-3-one Tesirine intermediate-1 1430738-05-8 C28H48N2O7Si2