ChemicalBook >> CAS DataBase List >>(6-{2-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester

(6-{2-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester

(6-{2-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester structure

CAS No.: 265989-40-0

Chemical Name:: (6-{2-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester

Synonyms: 2-Hydroxy Atorvastatin Acetonide tert-Butyl Ester;(6-{2-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester;(4R,6R)-6-[2-[2-(4-Fluorophenyl)-4-[[(2-hydroxyphenyl)aMino]carbonyl]-5-(1-Methylethyl)-3-phenyl-1H-pyrrol-1-yl]ethyl]-2,2-diMethyl-1,3-dioxane-4-acetic Acid 1,1-DiMethylethyl Ester;1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-4-[[(2-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-

CBNumber:: CB91175351

Molecular Formula:: C40H47FN2O6

Molecular Weight:: 670.81

MDL Number:: MFCD07369404

MOL File:: 265989-40-0.mol

Last updated:2023-05-05 08:29:07

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(6-{2-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester Properties

Boiling point	694.8±55.0 °C(Predicted)
Density	1.18±0.1 g/cm3(Predicted)
solubility	Acetone, Chloroform, Dichloromethane, Ethyl Acetate
pka	9.33±0.35(Predicted)
form	Solid
color	White Foamy

(6-{2-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	F595715	2-HydroxyAtorvastatinAcetonidetert-ButylEster	265989-40-0	2mg	$85	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0069081	(6-(2-(2-(4-FLUORO-PHENYL)-4-(2-HYDROXY-PHENYLCARBAMOYL)-5-ISOPROPYL-3-PHENYL-PYRROL-1-YL)-ETHYL)-2,2-DIMETHYL-(1,3)-DIOXANE-4-YL)-ACETIC ACID, TERT-BUTYL ESTER 95.00%	265989-40-0	1MG	$739.2	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0069081	(6-(2-(2-(4-FLUORO-PHENYL)-4-(2-HYDROXY-PHENYLCARBAMOYL)-5-ISOPROPYL-3-PHENYL-PYRROL-1-YL)-ETHYL)-2,2-DIMETHYL-(1,3)-DIOXANE-4-YL)-ACETIC ACID, TERT-BUTYL ESTER 95.00%	265989-40-0	100MG	$2055.9	2021-12-16	Buy
Medical Isotopes, Inc.	65015	2-HydroxyAtorvastatinAcetonidetert-ButylEster	265989-40-0	50mg	$2120	2021-12-16	Buy

Product number	Packaging	Price	Buy
F595715	2mg	$85	Buy
HCH0069081	1MG	$739.2	Buy
HCH0069081	100MG	$2055.9	Buy
65015	50mg	$2120	Buy

(6-{2-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester Chemical Properties,Uses,Production

Chemical Properties

White Foamy Solid

Uses

A intermediate of the metabolite of Atorvastin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

Uses

An intermediate of the metabolite of Atorvastin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

(6-{2-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester synthesis

Synthesis of (6-{2-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester from 2-BENZYLOXYANILINE

(6-{2-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester Preparation Products And Raw materials

Raw materials

(6-{2-[3-(2-Benzyloxy-phenylcarbamoyl)-5-(4-fluoro-phenyl)-2-isopropyl-4-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester 2-BENZYLOXYANILINE

Preparation Products

(6-{2-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester Suppliers

Global( 8)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	sales@rrkchem.com	China	55894	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chemsky（shanghai）International Co.,Ltd.	50
Shenzhen Polymeri Biochemical Technology Co., Ltd.	58
Energy Chemical	58

(6-{2-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester (4R,6R)-6-[2-[2-(4-Fluorophenyl)-4-[[(2-hydroxyphenyl)aMino]carbonyl]-5-(1-Methylethyl)-3-phenyl-1H-pyrrol-1-yl]ethyl]-2,2-diMethyl-1,3-dioxane-4-acetic Acid 1,1-DiMethylethyl Ester 2-Hydroxy Atorvastatin Acetonide tert-Butyl Ester 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-4-[[(2-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)- 265989-40-0 Intermediates