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ChemicalBook >> CAS DataBase List >>L-Phenylalaninamide, (4S)-hexahydro-2,6-dioxo-4-pyrimidinecarbonyl-L-phenylalanyl-L-ornithyl-L-prolyl-5-methyl-L-norleucyl-4-fluoro-L-phenylalanyl-

L-Phenylalaninamide, (4S)-hexahydro-2,6-dioxo-4-pyrimidinecarbonyl-L-phenylalanyl-L-ornithyl-L-prolyl-5-methyl-L-norleucyl-4-fluoro-L-phenylalanyl-

L-Phenylalaninamide, (4S)-hexahydro-2,6-dioxo-4-pyrimidinecarbonyl-L-phenylalanyl-L-ornithyl-L-prolyl-5-methyl-L-norleucyl-4-fluoro-L-phenylalanyl- Structure
L-Phenylalaninamide, (4S)-hexahydro-2,6-dioxo-4-pyrimidinecarbonyl-L-phenylalanyl-L-ornithyl-L-prolyl-5-methyl-L-norleucyl-4-fluoro-L-phenylalanyl- structure
CAS No.
1254036-23-1
Chemical Name:
L-Phenylalaninamide, (4S)-hexahydro-2,6-dioxo-4-pyrimidinecarbonyl-L-phenylalanyl-L-ornithyl-L-prolyl-5-methyl-L-norleucyl-4-fluoro-L-phenylalanyl-
Synonyms
JPE-1375;Hoo-Phe-Orn-Pro-HomoLeu-Phe(4-F)-Phe-NH2;L-Phenylalaninamide, (4S)-hexahydro-2,6-dioxo-4-pyrimidinecarbonyl-L-phenylalanyl-L-ornithyl-L-prolyl-5-methyl-L-norleucyl-4-fluoro-L-phenylalanyl-
CBNumber:
CB912151797
Molecular Formula:
C49H63FN10O9
Molecular Weight:
955.1
MDL Number:
MOL File:
1254036-23-1.mol
Last updated:2025-10-28 16:00:23
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L-Phenylalaninamide, (4S)-hexahydro-2,6-dioxo-4-pyrimidinecarbonyl-L-phenylalanyl-L-ornithyl-L-prolyl-5-methyl-L-norleucyl-4-fluoro-L-phenylalanyl- Properties

Density 1.280±0.06 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 100 mg/mL (104.70 mM; Need ultrasonic)
form Solid
pka 10.38±0.40(Predicted)
color White to off-white

L-Phenylalaninamide, (4S)-hexahydro-2,6-dioxo-4-pyrimidinecarbonyl-L-phenylalanyl-L-ornithyl-L-prolyl-5-methyl-L-norleucyl-4-fluoro-L-phenylalanyl- Chemical Properties,Uses,Production

Uses

JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC50=6.9 μM) and reduces TNF levels (EC50=4.5 μM) in mice. JPE-1375 can be used in studies of autoimmune and inflammatory diseases[1].

in vivo

JPE-1375 (0.3, 1.0, 3.0 mg/kg; i.v.; single) inhibits PMN (polymorphonuclear leukocytes) mobilization and TNF with EC50 values of 6.9 and 4.5 μM, respectively[1].
JPE-1375 (1 mg/kg; i.v.; single) demonstrates a rapid distribution in the plasma, followed by elimination in mice[1].
JPE-1375 (1 mg/kg; i.v.; single) shows a strong negative correlation between PMN mobilization and TNF production with plasma concentrations[1].

Animal Model:C57BL/6J wild-type (10 to 12-week-old; C5a pharmacodynamic model)[1].
Dosage:0.3, 1.0, 3.0 mg/kg
Administration:Intravenous injection; single.
Result:Significantly decreased C5a-mediated PMN mobilization at 1 and 3 mg/kg doses, while no effect was observed at a 0.3 mg/kg dose.
Showed a significant reduction in TNF plasma levels at 1 and 3 mg/kg dose with both compounds reducing C5a-mediated TNF by about 90%.
Animal Model:C57BL/6J wild-type mice(10 to 12-week-old)[1].
Dosage:1 mg/kg
Administration:Intravenous injection; single.
Result:1.19Pharmacokinetic Parameters of JPE-1375 in C57BL/6J wild-type mice[1].
IV (1 mg/kg)
T1/2 (h)0.13
Cmax (μg/mL)7.18
AUC0-t (μg/mL?h)2.40
AUC0-inf, obs (μg/mL?h)2.41
AUC0-t/0-inf, obs (μg/mL?h)1.00
AUMC0-inf, obs (μg/mL?h2)0.13
MRT0-inf, obs (h)0.05
Vz, obs ((μg)/(μg/mL))2.38
CL, obs ((μg)/(μg/mL)/h)12.47
Vss, obs ((μg)/(μg/mL))0.66

References

[1] Cui CS, et al. In Vivo Pharmacodynamic Method to Assess Complement C5a Receptor Antagonist Efficacy. ACS Pharmacol Transl Sci. 2021 Dec 21;5(1):41-51. DOI:10.1021/acsptsci.1c00227

L-Phenylalaninamide, (4S)-hexahydro-2,6-dioxo-4-pyrimidinecarbonyl-L-phenylalanyl-L-ornithyl-L-prolyl-5-methyl-L-norleucyl-4-fluoro-L-phenylalanyl- Preparation Products And Raw materials

Raw materials

Preparation Products

L-Phenylalaninamide, (4S)-hexahydro-2,6-dioxo-4-pyrimidinecarbonyl-L-phenylalanyl-L-ornithyl-L-prolyl-5-methyl-L-norleucyl-4-fluoro-L-phenylalanyl- Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39035 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 18101056239 3193328036@qq.com China 29759 68
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919 Eric@peptidego.com China 7408 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24961 58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD 0571-87213919 17306812703 3007955328@qq.com China 6979 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5002 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
Guangzhou Lucheng Biotechnology Co., Ltd. 16620452357 CHINA 0 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Hangzhou Peptidego Biotech Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
RD International Technology Co., Limited 58
Guangzhou Lucheng Biotechnology Co., Ltd. 58

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Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JPE-1375 pictures 2025-10-27 JPE-1375
1254036-23-1
 US $122.00 / mg 10g TargetMol Chemicals Inc.
  • JPE-1375 pictures
  • JPE-1375
    1254036-23-1
  • US $122.00 / mg
  • TargetMol Chemicals Inc.
L-Phenylalaninamide, (4S)-hexahydro-2,6-dioxo-4-pyrimidinecarbonyl-L-phenylalanyl-L-ornithyl-L-prolyl-5-methyl-L-norleucyl-4-fluoro-L-phenylalanyl- Hoo-Phe-Orn-Pro-HomoLeu-Phe(4-F)-Phe-NH2 JPE-1375 1254036-23-1 C49H63FN10O9