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2-Propen-1-one, 1-[4-[(7aS,8R)-4-(difluoromethyl)-7,7a,8,9-tetrahydro-2-[(2R,4S)-4-[2-(3-methoxy-3-oxetanyl)-4-methyl-3-pyridinyl]-2-methyl-1-piperidinyl]azeto[1,2-a]pyrido[3,4-f]azepin-8-yl]-1-piperazinyl]-

2-Propen-1-one, 1-[4-[(7aS,8R)-4-(difluoromethyl)-7,7a,8,9-tetrahydro-2-[(2R,4S)-4-[2-(3-methoxy-3-oxetanyl)-4-methyl-3-pyridinyl]-2-methyl-1-piperidinyl]azeto[1,2-a]pyrido[3,4-f]azepin-8-yl]-1-piperazinyl]- Structure
2-Propen-1-one, 1-[4-[(7aS,8R)-4-(difluoromethyl)-7,7a,8,9-tetrahydro-2-[(2R,4S)-4-[2-(3-methoxy-3-oxetanyl)-4-methyl-3-pyridinyl]-2-methyl-1-piperidinyl]azeto[1,2-a]pyrido[3,4-f]azepin-8-yl]-1-piperazinyl]- structure
CAS No.
3034851-27-6
Chemical Name:
2-Propen-1-one, 1-[4-[(7aS,8R)-4-(difluoromethyl)-7,7a,8,9-tetrahydro-2-[(2R,4S)-4-[2-(3-methoxy-3-oxetanyl)-4-methyl-3-pyridinyl]-2-methyl-1-piperidinyl]azeto[1,2-a]pyrido[3,4-f]azepin-8-yl]-1-piperazinyl]-
Synonyms
KRAS G12C inhibitor 68;2-Propen-1-one, 1-[4-[(7aS,8R)-4-(difluoromethyl)-7,7a,8,9-tetrahydro-2-[(2R,4S)-4-[2-(3-methoxy-3-oxetanyl)-4-methyl-3-pyridinyl]-2-methyl-1-piperidinyl]azeto[1,2-a]pyrido[3,4-f]azepin-8-yl]-1-piperazinyl]-
CBNumber:
CB914686145
Molecular Formula:
C35H44F2N6O3
Molecular Weight:
634.76
MDL Number:
MOL File:
3034851-27-6.mol
Last updated:2025-04-17 18:22:24
Request For Quotation

2-Propen-1-one, 1-[4-[(7aS,8R)-4-(difluoromethyl)-7,7a,8,9-tetrahydro-2-[(2R,4S)-4-[2-(3-methoxy-3-oxetanyl)-4-methyl-3-pyridinyl]-2-methyl-1-piperidinyl]azeto[1,2-a]pyrido[3,4-f]azepin-8-yl]-1-piperazinyl]- Properties

Boiling point 825.2±65.0 °C(predicted)
Density 1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka 6.55±0.40(predicted)

2-Propen-1-one, 1-[4-[(7aS,8R)-4-(difluoromethyl)-7,7a,8,9-tetrahydro-2-[(2R,4S)-4-[2-(3-methoxy-3-oxetanyl)-4-methyl-3-pyridinyl]-2-methyl-1-piperidinyl]azeto[1,2-a]pyrido[3,4-f]azepin-8-yl]-1-piperazinyl]- Chemical Properties,Uses,Production

Uses

KRAS G12C inhibitor 68 (compound I-063) is a KRAS G12C inhibitor with an IC50 of 7 nM. KRAS G12C inhibitor 68 has anti-tumor activity[1].

IC 50

KRas G12C: 7 nM (IC50)

References

[1] Brian A. Lanman, et al. Tethered heterocyclic inhibitors of kras g12c mutant proteins and uses thereof. WO2024076670A3.2024-05-30.

2-Propen-1-one, 1-[4-[(7aS,8R)-4-(difluoromethyl)-7,7a,8,9-tetrahydro-2-[(2R,4S)-4-[2-(3-methoxy-3-oxetanyl)-4-methyl-3-pyridinyl]-2-methyl-1-piperidinyl]azeto[1,2-a]pyrido[3,4-f]azepin-8-yl]-1-piperazinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Propen-1-one, 1-[4-[(7aS,8R)-4-(difluoromethyl)-7,7a,8,9-tetrahydro-2-[(2R,4S)-4-[2-(3-methoxy-3-oxetanyl)-4-methyl-3-pyridinyl]-2-methyl-1-piperidinyl]azeto[1,2-a]pyrido[3,4-f]azepin-8-yl]-1-piperazinyl]- Suppliers

Global( 1)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29545 58
Supplier Advantage
TargetMol Chemicals Inc. 58
2-Propen-1-one, 1-[4-[(7aS,8R)-4-(difluoromethyl)-7,7a,8,9-tetrahydro-2-[(2R,4S)-4-[2-(3-methoxy-3-oxetanyl)-4-methyl-3-pyridinyl]-2-methyl-1-piperidinyl]azeto[1,2-a]pyrido[3,4-f]azepin-8-yl]-1-piperazinyl]- KRAS G12C inhibitor 68 3034851-27-6