ANTI-NEUROFILAMENT 68
- CAS No.
- Chemical Name:
- ANTI-NEUROFILAMENT 68
- Synonyms
- ANTI-NF-L;Anti-NF68;Anti-CMT1F;Anti-CMT2E;ANTI-NEUROFILAMENT 68;ANTI-NEUROFILAMENT 68KD;ANTI-NEUROFILAMENT LIGHT;ANTI-NEUROFILAMENT 70 KD;ANTI-NEUROFILAMENT 68 KDA, HUMAN;ANTI-NEUROFILAMENT, BOVINE, 68KD
- CBNumber:
- CB9185854
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD02097017
- MOL File:
- Mol file
ANTI-NEUROFILAMENT 68 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | N5139 | Monoclonal Anti-Neurofilament 68 antibody produced in mouse clone NR4, ascites fluid | 0.2ML | $394.2 | 2024-03-01 | Buy | |
Sigma-Aldrich | N5139 | Monoclonal Anti-Neurofilament 68 antibody produced in mouse clone NR4, ascites fluid | 100μL | $499 | 2024-03-01 | Buy |
ANTI-NEUROFILAMENT 68 Chemical Properties,Uses,Production
Uses
Monoclonal Anti-Neurofilament 68 antibody has been used:
- in immunohistochemistry
- in immunoblotting
- in western blotting
General Description
Monclonal Anti-Neurofilament 68 (mouse IgG1 isotype) is produced by the fusion mouse myeloma cells and splenocytes from an immunized mouse. Neurofilaments are composed of three sub-units- light NFL protein, medium NFM protein, heavy NFH protein. Along with there two other intermediate filaments are present α-internexin and peripherin. Neurofilaments are phosphoproteins. The neurofilaments are one of the five major groups of IFs and are found predominantly in cells or tissues of neuronal origin. They are composed of three major proteins of apparent molecular weights 68 kD, 95kD, and 115kD. Neurofilament proteins are synthesized in the neuronal perikarya, assembled to form filaments and then slowly transported within the axons towards the synaptic terminals.
Biochem/physiol Actions
Neurofilaments undergo post-translational modification, which results in their heterogeneity, including different levels of phosphorylation. The phosphorylation of neurofilament polypeptides has been suggested to modulate their function by influencing the interaction between neurofilament and cytoplasmic organelles. Neurofilaments play a role in axonal calibre as they help in movement of an impulse down the axon. Their activity depends on phosphorylation of neurofilaments.Mutations of neurofilaments causes Charcot-Marie-Tooth (CMT) disease. Accumulation of neurofilaments has been observed in many human neurological diseases like Alzheimer′s disease, progressive supranuclear palsy, diabetic neuropathy, and giant axonal neuropathy.
ANTI-NEUROFILAMENT 68 Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-NEUROFILAMENT 68 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Riedel-de Haen AG | -- | United States | 6825 | 87 | |
SIGMA-RBI | -- | Switzerland | 6913 | 91 | |
EMD Biosciences, Inc. | -- | technical@calbiochem.com | United States | 6529 | 66 |
BIOTREND Chemikalien GmbH | -- | jaeger@biotrend.com | Germany | 6115 | 76 |
Zymed Laboratories Inc. | -- | United States | 3068 | 86 | |
MP Biomedicals, Inc. | -- | United States | 6566 | 81 | |
Novus Biologicals, Inc. | -- | novus@novusbio.com | United States | 175 | 77 |
Vision BioSystems | -- | sales.usa@vision-bio.com | United States | 542 | 74 |
Cortex Biochem, Inc. | -- | info@cortex-biochem.com | United States | 1557 | 77 |
Chemicon Internatinal, Inc. | -- | custserv@chemicon.com | United States | 4175 | 65 |
Supplier | Advantage |
---|---|
Riedel-de Haen AG | 87 |
SIGMA-RBI | 91 |
EMD Biosciences, Inc. | 66 |
BIOTREND Chemikalien GmbH | 76 |
Zymed Laboratories Inc. | 86 |
MP Biomedicals, Inc. | 81 |
Novus Biologicals, Inc. | 77 |
Vision BioSystems | 74 |
Cortex Biochem, Inc. | 77 |
Chemicon Internatinal, Inc. | 65 |