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GSK1904529A

GSK1904529A structure

CAS No.: 1089283-49-7

Chemical Name:: GSK1904529A

Synonyms: CS-29;GSK 4529;GSK1904529A;GSK1904529A, >=98%;GSK1904529A (GSK-4529;IGF-IR, IGF-IIR inhibitor;IGF-1R inhibitor GS1904529A;GSK1904529A ISO 9001：2015 REACH;GSK1904529A;GSK-1904529A;GSK 1904529A;GSK1904529A : IGF-IR, IGF-IIR inhibitor

CBNumber:: CB92501005

Molecular Formula:: C44H47F2N9O5S

Molecular Weight:: 851.96

MDL Number:: MFCD17010271

MOL File:: 1089283-49-7.mol

MSDS File:: SDS

Last updated:2023-06-08 09:03:01

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GSK1904529A Properties

Density	1.39
storage temp.	Store at -20°C
solubility	≥42.6 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form	solid
pka	11.12±0.70(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

NFPA 704

	0
2		0

GSK1904529A price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	29155	GSK1904529A	1089283-49-7	5mg	$116	2024-03-01	Buy
Cayman Chemical	29155	GSK1904529A	1089283-49-7	25mg	$456	2024-03-01	Buy
Cayman Chemical	29155	GSK1904529A	1089283-49-7	1mg	$32	2024-03-01	Buy
Cayman Chemical	29155	GSK1904529A	1089283-49-7	10mg	$214	2024-03-01	Buy
TRC	G797490	GSK1904529A	1089283-49-7	5mg	$170	2021-12-16	Buy

Product number	Packaging	Price	Buy
29155	5mg	$116	Buy
29155	25mg	$456	Buy
29155	1mg	$32	Buy
29155	10mg	$214	Buy
G797490	5mg	$170	Buy

GSK1904529A Chemical Properties,Uses,Production

Uses

GSK 1904529A is a small-molecule inhibitor of the insulin-like growth factor-I receptor tyrosine kinase.

Uses

A selective inhibitor of IGF-1R and IR with IC50s of 27 nM and 25 nM, respectively.

Definition

ChEBI: N-(2,6-difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonyl-1-piperazinyl)-1-piperidinyl]anilino]-4-pyrimidinyl]-2-imidazo[1,2-a]pyridinyl]-2-methoxybenzamide is a member of benzamides.

Biological Activity

gsk1904529a is a small-molecule inhibitor of the insulin-like growth factor-i receptor (igf-ir) with ic50 value of 27 nm 1.gsk1904529a is a reversible and atp-competitive inhibitor with ki value of 1.6 nm. in nih-3t3/lisn cells, gsk1904529a potently inhibited phosphorylation of igf-ir with ic50 value of 22 nm. it also demonstrated to be a selective inhibitor since it showed poor inhibitory activity against 45 other serine/threonine and tyrosine kinases. when treated with whole-cell extracts, gsk1904529a significantly inhibited the ligand-induced phosphorylation of igf-ir and decreased phosphorylation of downstream signaling including akt, irs-1 and erk at concentrations > 0.01μm. gsk1904529a suppressed cell proliferation in a variety of tumor cells. the ic50 values for nci-h929, tc-71, sk-n-mc, colo 205, mcf7 and prec are 81, 35, 43, 124, 137 and 68 nm, respectively. in colo 205, mcf-7, and nci-h929 cells, gsk1904529a treatment resulted in cell accumulation in g1 and decrease in s and g2-m phases. moreover, in nih-3t3/lisn xenograft model, once daily administration of gsk1904529a at 30 mg/kg inhibited 56% of tumor growth 1.

target

IGF1R

References

1. sabbatini p, rowand j l, groy a, et al. antitumor activity of gsk1904529a, a small-molecule inhibitor of the insulin-like growth factor-i receptor tyrosine kinase. clinical cancer research, 2009, 15(9): 3058-3067.

GSK1904529A Preparation Products And Raw materials

Raw materials

5-(3-(2-chloropyriMidin-4-yl)iMidazo[1,2-a]pyridin-2-yl)-N-(2,6-difluorophenyl)-2-MethoxybenzaMide 5-ethyl-2-Methoxy-4-(4-(4-(Methylsulfonyl)piperazin-1-yl)piperidin-1-yl)aniline

Preparation Products

GSK1904529A Suppliers

Global( 108)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9271	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29118	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Hubei Jusheng Technology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58

View Lastest Price from GSK1904529A manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-04-17	GSK1904529A 1089283-49-7	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
	2021-10-12	GSK1904529A 1089283-49-7	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited

GSK1904529A
1089283-49-7
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

GSK1904529A
1089283-49-7
US $1.10 / g
99.00%
Dideu Industries Group Limited

GSK1904529A Spectrum

GSK1904529A(1089283-49-7)¹HNMR

1089283-49-7(GSK1904529A)Related Search:

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GSK 4529 GSK1904529A GSK1904529A : IGF-IR, IGF-IIR inhibitor N-(2,6-Difluorophenyl)-5-[3-[2-[[5-ethyl-2-(methyloxy)-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-pyrimidinyl]imidazo[1,2-a]pyridin-2-yl]-2-(methyloxy)benzamide N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-4-(4-(4-(methylsulfonyl)piperazin-1-yl)piperidin-1-yl)phenylamino)pyrimidin-4-yl)H-imidazo[1,2-a]pyridin-2-yl)-2-methoxybenzamide N-(2,6-Difluorophenyl)-5-[3-[2-[[5-ethyl-2-(methyloxy)-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-pyrimidinyl]imidazo[1,2-a]pyridin-2-yl]-2-(methyloxy)benzamide GSK 1904529A GSK1904529A, >=98% IGF-IR, IGF-IIR inhibitor N-(2,6-Difluorophenyl)-5-[3-[2-[[5-ethyl-2-(methyloxy)-4-[4-[4-(methylsulfonyl)-1-piperazinyl] CS-29 GSK1904529A;GSK-1904529A;GSK 1904529A Benzamide, N-(2,6-difluorophenyl)-5-[3-[2-[[5-ethyl-2-methoxy-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-pyrimidinyl]imidazo[1,2-a]pyridin-2-yl]-2-methoxy- GSK1904529A ISO 9001：2015 REACH GSK1904529A (GSK-4529 N-(2,6-Difluorophenyl)-5-(3-(2-((5-ethyl-2-methoxy-4-(4-(4-(methylsulfonyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)-2-methoxybenzamide IGF-1R inhibitor GS1904529A 1089283-49-7 C44H47F2N9O5S Inhibitors