Amino-PEG4-acid
- CAS No.
- 663921-15-1
- Chemical Name:
- Amino-PEG4-acid
- Synonyms
- 1-AMino-3,6,9,12-tetraoxapentadecan-15-oic acid;NH2-PEG4-COOH;Amino-PEG4-acid;NH2-PEG4-CH2CH2COOH;3-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]propionic acid;NH2-PEG4-PA;Amino-PEG4-COOH;AMINE-PEG4-COOH;amino-dPEG4-acid;Amino-dPEGx-acid
- CBNumber:
- CB92501434
- Molecular Formula:
- C11H23NO6
- Molecular Weight:
- 265.3
- MDL Number:
- MFCD11041129
- MOL File:
- 663921-15-1.mol
| Boiling point | 409.6±40.0 °C(Predicted) |
|---|---|
| Density | 1.134±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 4.28±0.10(Predicted) |
| form | powder |
| color | White |
| InChI | InChI=1S/C11H23NO6/c12-2-4-16-6-8-18-10-9-17-7-5-15-3-1-11(13)14/h1-10,12H2,(H,13,14) |
| InChIKey | DKUZHSDZSMQOGQ-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CCOCCOCCOCCOCCN |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P301+P312-P261 |
| HS Code | 2942000090 |
Amino-PEG4-acid price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | QBD10244 | Amino-dPEG®4-acid >95% (HPLC) | 663921-15-1 | 100MG | $170 | 2024-03-01 | Buy |
| TRC | H289595 | H2N-Dpeg(4)-COOH | 663921-15-1 | 100mg | $110 | 2021-12-16 | Buy |
| BroadPharm | BP-20423 | Amino-PEG4-acid 98% | 663921-15-1 | 1g | $320 | 2021-12-16 | Buy |
| dPEG | 10244 | Amino-dPEG®₄-acid | 663921-15-1 | 1000mg | $350 | 2021-12-16 | Buy |
| Activate Scientific | AS114327 | H2N-PEG4-CH2CH2COOH 97+% | 663921-15-1 | 1g | $398 | 2021-12-16 | Buy |
Amino-PEG4-acid Chemical Properties,Uses,Production
Description
Amino-PEG4-acid is a very popular PEG linker. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond, long PEG spacer increases reagent's solubility in aqueous media.
Uses
H2N-Dpeg(4)-COOH, can be used in optical imaging of integrin αvβ3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers. Integrin αvβ3 plays great roles in tumor angiogenesis, invasion, and metastasis.
benefits
Amino-dPEG4-acid has a primary amine and propionic acid terminating opposite ends of a 16-atoms long (18.0 ?) polyethylene glycol (PEG) spacer. The single molecular weight PEG spacer is discrete (D = 1). Moreover, it is highly hydrophilic, and it imparts hydrophilicity to conjugates that incorporate it. Amino-dPEG4-acid is useful in many different applications, including peptide synthesis, surface modification, dendrimer construction, and small molecule modification.
References
1. Improving tumor-targeting capability and pharmacokinetics of (99m)Tc-labeled cyclic RGD dimers with PEG(4) linkers. DOI:10.1021/mp800150r
2. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. DOI:10.1021/bc400050k
3. Microwave-mediated synthesis of labeled nucleotides with utility in the synthesis of DNA probes. DOI:10.1021/bc100013b
4. Improving tumor uptake and pharmacokinetics of (64)Cu-labeled cyclic RGD peptide dimers with Gly(3) and PEG(4) linkers. DOI:10.1021/bc800455p
Amino-PEG4-acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@airuikechemical.com | China | 994 | 58 |
| 9i LLC | +18039569191 | MWan@NiNeiLab.com | United States | 418 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Chengdu Pukang Biotechnology Co., Ltd | 028-82550498 | export@pu-kang.com | CHINA | 210 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Wuhan Borenpharm Co., Ltd | 027-65563561 18717150066 | 3207347307@qq.com | CHINA | 1238 | 58 |
View Lastest Price from Amino-PEG4-acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-08 | α-amine-ω-propionic acid tetraethylene glycol
663921-15-1
|
US $0.00-0.00 / Kg | 1Kg | 99.9% | 200tons | airuikechemical co., ltd. | |
 |
2024-03-23 | Amino-PEG4-COOH
663921-15-1
|
US $0.00 / g | 5g | >98.00% | 25g | Xian confluore Biological Technology Co., Ltd. | |
 |
2019-07-06 | α-amine-ω-propionic acid tetraethylene glycol
663921-15-1
|
US $8.80 / KG | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- α-amine-ω-propionic acid tetraethylene glycol
663921-15-1
- US $0.00-0.00 / Kg
- 99.9%
- airuikechemical co., ltd.
-
- Amino-PEG4-COOH
663921-15-1
- US $0.00 / g
- >98.00%
- Xian confluore Biological Technology Co., Ltd.
-
- α-amine-ω-propionic acid tetraethylene glycol
663921-15-1
- US $8.80 / KG
- 97%-99%
- Career Henan Chemical Co
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