Tubulysin A,TubA
- CAS No.
- 205304-86-5
- Chemical Name:
- Tubulysin A,TubA
- Synonyms
- TubA;CS-1324;Tubulysin A;Tubulysins A;Tubulysin A,TubA;(2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoicaci;Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(3-methyl-1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-
- CBNumber:
- CB92518395
- Molecular Formula:
- C43H65N5O10S
- Molecular Weight:
- 844.07
- MDL Number:
- MFCD12912448
- MOL File:
- 205304-86-5.mol
- MSDS File:
- SDS
| Melting point | 106-108 °C(Solv: methanol (67-56-1); water (7732-18-5)) |
|---|---|
| Boiling point | 979.9±65.0 °C(Predicted) |
| Density | 1.195±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | organic solvents: soluble |
| form | film |
| pka | 4.52±0.23(Predicted) |
| color | colorless or white |
| biological source | Streptomyces sp. |
| FDA UNII | X9RP3ADE9Z |
| UNSPSC Code | 12352202 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H311-H315-H319-H331-H335 |
| Precautionary statements | P261-P280-P301+P310-P305+P351+P338-P311 |
| Hazard Codes | T |
| Risk Statements | 23/24/25-36/37/38 |
| Safety Statements | 36/37-45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
Tubulysin A,TubA price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | T897135 | TubulysinA | 205304-86-5 | 0.25mg | $385 | 2021-12-16 | Buy |
| TRC | T897135 | TubulysinA | 205304-86-5 | 1mg | $1405 | 2021-12-16 | Buy |
| TRC | T897135 | TubulysinA | 205304-86-5 | 2.5mg | $2805 | 2021-12-16 | Buy |
| TRC | T897135 | TubulysinA | 205304-86-5 | 5mg | $4235 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0004574 | TUBULYSIN A 95.00% | 205304-86-5 | 1MG | $2684.85 | 2021-12-16 | Buy |
Tubulysin A,TubA Chemical Properties,Uses,Production
Uses
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative.
Definition
ChEBI: Tubulysin A is a diester and a carboxylic acid.
Biochem/physiol Actions
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.
in vivo
Tubulysin A (0.04 mg/kg, 0.06 mg/kg; Intraperitoneal (i.p.); once daily for 4 days) can inhibit the growth of tumor cells in mouse xenotransplantation model[1].
| Animal Model: | Mouse xenotransplantation model[1] |
| Dosage: | 0.04 and 0.06 mg/kg |
| Administration: | Intraperitoneal (i.p.) |
| Result: | Inhibited the growth of tumor cells. |
IC 50
Traditional Cytotoxic Agents
Tubulysin A,TubA Preparation Products And Raw materials
Raw materials
Preparation Products
Tubulysin A,TubA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| ChemExpress | +86-021-58950125 +86-021-58950125; | info@chemexpress.com | China | 785 | 58 |
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53900 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| career henan chemical co | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | 58 |
| ChemExpress | 58 |
| Alfa Chemistry | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | 58 |
| MedChemexpress LLC | 58 |
| Sigma-Aldrich | 80 |
| SPIRO PHARMA | 55 |
View Lastest Price from Tubulysin A,TubA manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | Tubulysin A,TubA
205304-86-5
|
US $1.00 / g | 1g | ≥98% | g/kg/Ton | Career Henan Chemical Co |
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- Tubulysin A,TubA
205304-86-5
- US $1.00 / g
- ≥98%
- Career Henan Chemical Co