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(S)-M8-SPy

(S)-M8-SPy structure

CAS No.: 1192364-56-9

Chemical Name:: (S)-M8-SPy

Synonyms: (S)-M8-SPy;(α1S,α4S,α7S,2S,5S,8S,11S)-α1,α4,α7,2,5,8,11-HeptaMethyl-10-[(1S)-1-Methyl-2-oxo-2-[[2-(2-pyridinyldithio)ethyl]aMino]ethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic Acid;1,4,7,10-Tetraazacyclododecane-1,4,7-triaceticacid, a1,a4,a7,2,5,8,11-heptamethyl-10-[(1S)-1-methyl-2-oxo-2-[[2-(2-pyridinyldithio)ethyl]amino]ethyl]-,(a1S,a4S,a7S,2S,5S,8S,11S)-;1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, α1,α4,α7,2,5,8,11-heptamethyl-10-[(1S)-1-methyl-2-oxo-2-[[2-(2-pyridinyldithio)ethyl]amino]ethyl]-, (α1S,α4S,α7S,2S,5S,8S,11S)-

CBNumber:: CB92551116

Molecular Formula:: C31H52N6O7S2

Molecular Weight:: 684.91

MDL Number:: MFCD28989016

MOL File:: 1192364-56-9.mol

Last updated:2023-05-15 10:43:47

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(S)-M8-SPy Properties

solubility	Water (Slightly)
form	Low-Melting Solid
color	Off-White to Pale Yellow
Stability	Hygroscopic

(S)-M8-SPy Chemical Properties,Uses,Production

Uses

Commonly used for caging lanthanides and other heavy metal ions in magnetic resonance imaging (1). Lanthanide Complexes based on DOTA cage are also utilized in structural NMR applications due to their ability to induce either paramagnetic relaxation enhancement or a pseudocontact shift (PCS) depending on the choice of the lanthanide (2).

Uses

(S)-M8-SPy is a new lanthanide chelating tag (M8) for paramagnetic labeling of biomols. is presented, which is based on an eight-fold, stereoselectively methyl-substituted DOTA that can be covalently linked to the host molecule by a single disulfide bond. The steric overcrowding of the DOTA scaffold leads to an extremely rigid, kinetically and chemically inert lanthanide chelator. Due to its exceptionally high stability and lanthanide affinity M8 can be used under extreme chemical or physical conditions, such as those applied for protein denaturation, or when it is undesirable that buffer or protein react with excess lanthanide ions.

(S)-M8-SPy Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-M8-SPy Suppliers

Global( 12)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44843	58

Supplier	Advantage
Chemsky (shanghai) International Co.,Ltd	60
Energy Chemical	58

(α1S,α4S,α7S,2S,5S,8S,11S)-α1,α4,α7,2,5,8,11-HeptaMethyl-10-[(1S)-1-Methyl-2-oxo-2-[[2-(2-pyridinyldithio)ethyl]aMino]ethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic Acid 1,4,7,10-Tetraazacyclododecane-1,4,7-triaceticacid, a1,a4,a7,2,5,8,11-heptamethyl-10-[(1S)-1-methyl-2-oxo-2-[[2-(2-pyridinyldithio)ethyl]amino]ethyl]-,(a1S,a4S,a7S,2S,5S,8S,11S)- (S)-M8-SPy 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, α1,α4,α7,2,5,8,11-heptamethyl-10-[(1S)-1-methyl-2-oxo-2-[[2-(2-pyridinyldithio)ethyl]amino]ethyl]-, (α1S,α4S,α7S,2S,5S,8S,11S)- 1192364-56-9 C31H52N6O7S2 Aromatics Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds