ADPM06
- CAS No.
- 490035-90-0
- Chemical Name:
- ADPM06
- Synonyms
- ADPM06;YVKIKMDAXWFEJI-UHFFFAOYSA-N;Bromoazadipyrromethane ADPM06
- CBNumber:
- CB92667822
- Molecular Formula:
- C34H24BBr2F2N3O2
- Molecular Weight:
- 715.1890664
- MDL Number:
- MFCD25976609
- MOL File:
- 490035-90-0.mol
- MSDS File:
- SDS
| Melting point | 271-273 °C |
|---|---|
| form | Solid |
| color | Brown to black |
| FDA UNII | M887PT8U5Y |
ADPM06 Chemical Properties,Uses,Production
Uses
ADPM06, a lead candidate azadipyrromethene, is a novel nonporphyrin photodynamic therapeutic (PDT) agent. ADPM06 exhibits IC50 values in the micro-molar range in human tumor cells and induces apoptosis[1].
in vivo
ADPM06-PDT has revealed an initiation of apoptosis in vivo, as well as induction of an ER stress response[2].
ADPM06-PDT is well tolerated in vivo and elicits impressive complete response rates in various models of cancer when a short drug-light interval is applied[2].
| Animal Model: | Female Balb C nu/nu mice[2]. |
| Dosage: | 2 mg/kg in 0.3 mL solution via the lateral tail vein. |
| Administration: | IV. |
| Result: | Revealed a rapid reduction in tumor-specific luciferase activity as early as 1-hr post-PDT, with levels decreasing further 4-hr post-PDT. |
References
[1] W M Gallagher, et al. A potent nonporphyrin class of photodynamic therapeutic agent: cellular localisation, cytotoxic potential and influence of hypoxia. Br J Cancer. 2005 May 9; 92(9): 1702-1710. DOI:10.1038/sj.bjc.6602527
[2] Aisling E O'Connor, et al. Mechanism of cell death mediated by a BF2-chelated tetraaryl-azadipyrromethene photodynamic therapeutic: dissection of the apoptotic pathway in vitro and in vivo. Int J Cancer. 2012 Feb 1;130(3):705-15. DOI:10.1002/ijc.26073
ADPM06 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shanghai Xianhui Pharmaceutical Co., Ltd. | 13564796979 | shxh2006@aliyun.com | China | 32 | 62 |
| Zhengzhou Akem Chemical Co., Ltd | 13303867194 | 3001317055@qq.com | China | 9680 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 6762 | 58 |
| Shaanxi Xihua Chemical Industry Co., Ltd | 029-029-81123119 17391733320 | 1021@dideu.com | China | 10000 | 58 |
| Changsha Fuzhen Biotechnology Co.，LTD | 0731-13823398 15111215862 | 313359644@qq.com | China | 4161 | 58 |
| Olix (Shanghai) Pharmaceutical Technology Co., Ltd | 17316404525 17316404525 | 209533805@qq.com | China | 9763 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
| Guangzhou Baide Biotechnology Co., Ltd. | 18925065404 | CHINA | 168 | 58 |
