Azido-PEG3-Maleimide
- CAS No.
- 1858264-36-4
- Chemical Name:
- Azido-PEG3-Maleimide
- Synonyms
- N3-PEG3-Mal;Azido-PEG4-BMPA;Azide-PEG3-maleimide;Azido-PEG3-Maleimide;1H-Pyrrole-1-propanamide, N-[2-[2-[2-(2-azidoethoxy) ethoxy] ethoxy] ethyl]-2,5-dihydro-2,5-dioxo-
- CBNumber:
- CB93162867
- Molecular Formula:
- C15H23N5O6
- Molecular Weight:
- 369.37302
- MDL Number:
- MFCD22380764
- MOL File:
- 1858264-36-4.mol
Azido-PEG3-Maleimide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Chem-Impex | 35111 | Azido-PEG3-maleimide | 1858264-36-4 | 5MG | $67.2 | 2021-12-16 | Buy |
| BroadPharm | BP-22468 | Azido-PEG3-Maleimide 95% | 1858264-36-4 | 25mg | $95 | 2021-12-16 | Buy |
| Chem-Impex | 35111 | Azido-PEG3-maleimide | 1858264-36-4 | 25MG | $123.2 | 2021-12-16 | Buy |
| ChemScene | CS-0114354 | Azido-PEG3-maleimide | 1858264-36-4 | 25mg | $165 | 2021-12-16 | Buy |
| BroadPharm | BP-22468 | Azido-PEG3-Maleimide 95% | 1858264-36-4 | 100mg | $195 | 2021-12-16 | Buy |
Azido-PEG3-Maleimide Chemical Properties,Uses,Production
Description
Azido-PEG3-Maleimide is provided as a kit of two vials. Azido-PEG3-Maleimide is not stable for storage; it needs to be made in situ by mixing Azido-PEG3-amine and Maleimide-NHS ester followed by shaking/ stirring for 30 minutes at room temperature. The maleimide group of the Azido-PEG3-Maleimide can react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. Azide group enables Click Chemsitry reactions.
Biological Activity
Azido-PEG3-maleimide is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules. Azido-PEG3-maleimide is also a cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| PEGs
| Cleavable
|
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Mashilabs (Shanghai) Co.,Ltd. | 021-00000000 19916721580 | info@mashilabs.com | China | 4115 | 58 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80514535 19917294565 | et@chemextension.com | China | 4111 | 55 |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6357 | 58 |