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ChemicalBook >> CAS DataBase List >>BAY 85-8501

BAY 85-8501

BAY 85-8501 Structure
BAY 85-8501 structure
CAS No.
1161921-82-9
Chemical Name:
BAY 85-8501
Synonyms
PHP-303;BAY 85-8501;BAY-85-8501, 10 mM in DMSO;inhibit,Elastase,Inhibitor,BAY 85 8501,BAY858501;(S)-4-(4-cyano-2-(methylsulfonyl)phenyl)-3,6-dimethyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidine-5-carbonitrile;5-Pyrimidinecarbonitrile, 4-[4-cyano-2-(methylsulfonyl)phenyl]-1,2,3,4-tetrahydro-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-, (4S)-
CBNumber:
CB93312279
Molecular Formula:
C22H17F3N4O3S
Molecular Weight:
474.46
MDL Number:
MFCD30532744
MOL File:
1161921-82-9.mol
Last updated:2025-04-30 13:36:08
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BAY 85-8501 Properties

Boiling point 626.7±55.0 °C(Predicted)
Density 1.49±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
pka -4.16±0.70(Predicted)
color White to off-white
FDA UNII U9DE68P1CA

BAY 85-8501 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0016945 BAY-85-8501 99.59% 1161921-82-9 5mg $550 2021-12-16 Buy
ChemScene CS-0016945 BAY-85-8501 99.59% 1161921-82-9 10mg $850 2021-12-16 Buy
ChemScene CS-0016945 BAY-85-8501 99.59% 1161921-82-9 25mg $1750 2021-12-16 Buy
ChemScene CS-0016945 BAY-85-8501 99.59% 1161921-82-9 50mg $2850 2021-12-16 Buy
ChemScene CS-0016945 BAY-85-8501 99.59% 1161921-82-9 100mg $3950 2021-12-16 Buy
Product number Packaging Price Buy
CS-0016945 5mg $550 Buy
CS-0016945 10mg $850 Buy
CS-0016945 25mg $1750 Buy
CS-0016945 50mg $2850 Buy
CS-0016945 100mg $3950 Buy

BAY 85-8501 Chemical Properties,Uses,Production

Uses

BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC50 of 65 pM.

in vivo

In this model the exogenous HNE noxa is the primary cause of injury and lung hemorrhage. Based on picomolar potency against HNE as well as single digit potency versus MNE, BAY-85-8501 (29) completely prevents the development of lung injury and subsequent inflammation when administered 1 h prior to the HNE noxa. In the 0.01 mg/kg dose group, hemoglobin concentration is already significantly decreased. At a dose of 0.1 mg/kg, a significant effect on neutrophil count is observed. In this setup, efficacy is predominantly driven by potency against HNE (Ki=0.08 nM). As the highly HNE-selective inhibitor BAY 85-8501 has no effect on PPE, BAY-85-8501 could not prevent the primary lung injury in this setup. Nevertheless, BAY-85-8501 could inhibit MNE, the endogenous driver of inflammation and secondary injury, although with decreased potency. Consequently, the effects of BAY-85-8501 on inflammation and secondary injury are weaker at this point, and only observed at 30-fold higher doses. Efficacy is predominantly driven by potency against MNE (Ki=6 nM) in this second setup[1].

References

[1] Von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73. DOI:10.1002/cmdc.201500131

BAY 85-8501 Preparation Products And Raw materials

Raw materials

Preparation Products

BAY 85-8501 Suppliers

Global( 29)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32281 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38665 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
DKMbiochem.Co. Ltd 15901859516 sales@DKMbiochem.com China 344 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 7988 62
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 17801761073 3193328036@qq.com China 29763 68
Supplier Advantage
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
BOC Sciences 65
DKMbiochem.Co. Ltd 58
Shanghai EFE Biological Technology Co., Ltd. 58
ShangHai Biochempartner Co.,Ltd 62
Beijing Solarbio Science & Tecnology Co., Ltd. 68

View Lastest Price from BAY 85-8501 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BAY-85-8501 pictures 2025-05-01 BAY-85-8501
1161921-82-9
 US $88.00-331.00 / mg 99.16% 10g TargetMol Chemicals Inc.
BAY-85-8501 pictures 2025-04-30 BAY-85-8501
1161921-82-9
 US $88.00-331.00 / mg 99.16% 10g TargetMol Chemicals Inc.
  • BAY-85-8501 pictures
  • BAY-85-8501
    1161921-82-9
  • US $88.00-331.00 / mg
  • 99.16%
  • TargetMol Chemicals Inc.
  • BAY-85-8501 pictures
  • BAY-85-8501
    1161921-82-9
  • US $88.00-331.00 / mg
  • 99.16%
  • TargetMol Chemicals Inc.

BAY 85-8501 Spectrum

BAY 85-8501(1161921-82-9)1HNMR
BAY 85-8501 PHP-303 5-Pyrimidinecarbonitrile, 4-[4-cyano-2-(methylsulfonyl)phenyl]-1,2,3,4-tetrahydro-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-, (4S)- (S)-4-(4-cyano-2-(methylsulfonyl)phenyl)-3,6-dimethyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidine-5-carbonitrile inhibit,Elastase,Inhibitor,BAY 85 8501,BAY858501 BAY-85-8501, 10 mM in DMSO 1161921-82-9