VU0469650
- CAS No.
- 1443748-47-7
- Chemical Name:
- VU0469650
- Synonyms
- VU0469650;CID73755207;VU 0469650 HCl;VU 0469650 hydrochloride;VU 0469650, 10 mM in DMSO;VU0469650|||VU 0469650|||VU-0469650|||VU 0469650 HCl;3-[(3R)-3-METHYL-4-[(4-METHYLADAMANTAN-1-YL)CARBONYL]PIPERAZIN-1-YL]PYRIDINE-2-CARBONITRILE;2-Pyridinecarbonitrile, 3-[(3R)-3-methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-;3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride
- CBNumber:
- CB93369783
- Molecular Formula:
- C22H28N4O
- Molecular Weight:
- 364.48
- MDL Number:
- MFCD30182286
- MOL File:
- 1443748-47-7.mol
| Boiling point | 584.7±50.0 °C(Predicted) |
|---|---|
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 100 mM,Ethanol: 50 mM |
| pka | 1.42±0.12(Predicted) |
| form | Solid |
| color | Off-white to light yellow |
| optical activity | [α]/D -41 to -51°, c =1 in methanol |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
VU0469650 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 5379 | VU0469650hydrochloride ≥98%(HPLC) | 1443748-47-7 | 10 | $208 | 2021-12-16 | Buy |
| Tocris | 5379 | VU0469650hydrochloride ≥98%(HPLC) | 1443748-47-7 | 50 | $870 | 2021-12-16 | Buy |
| TRC | V787585 | VU0469650Hydrochloride | 1443748-47-7 | 5mg | $115 | 2021-12-16 | Buy |
VU0469650 Chemical Properties,Uses,Production
Uses
VU 0469650 Hydrochloride is potent and selective negative allosteric modulators of metabotropic glutamate receptor 1 (mGlu1).
Biological Activity
VU0469650 is a brain-penetrant, potent and selective metabotropic glutamate receptor 1 (mGlu1) negative allosteric modulator (NAM). VU0469650 selectively inhibits glu-induced Ca2+ influx in human mGluR1-expressing HEK 293A (EC50 = 99 nM with [Glu] = EC20 for 1.9 min, then EC100 for 1.7 min; inactive against cells expressing human mGlu2-8 at 10 μM) with no affinity toward a panel of 68 clinically relevant GPCRs, ion channels, kinases, and transporters. Prior administration of VU0469650 in mice in vivo (60 mg/kg i.p.) modulates the antipsychotic activity of M4 muscarinic receptor PAM VU0467154 and th at of the M1/M4 agonist xanomeline.
in vivo
VU0469650 (male Sprague-Dawley rats, 0.2 mg/kg, IV, once) exhibits moderate to high clearance, a moderate volume of distribution, and a half-life of approximately 1 hour[1].
VU0469650 (male Sprague-Dawley rats, 10 mg/kg, IP, once) shows an excellent selectivity profile and good exposure in both plasma and brain samples[1].
IC 50
mGluR 1: 99 nM (IC50)
storage
Store at +4°C
VU0469650 Preparation Products And Raw materials
Raw materials
Preparation Products
VU0469650 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32239 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38648 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 993 | 55 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9342 | 58 |
| Jinan Yaoyan Pharmaceutical Co., Ltd. | jnyaoyan@163.com | China | 3069 | 58 | |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19103 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 947 | 58 |
View Lastest Price from VU0469650 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | VU 0469650
1443748-47-7
|
US $61.00-193.00 / mg | 97.27% | 10g | TargetMol Chemicals Inc. |
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- VU 0469650
1443748-47-7
- US $61.00-193.00 / mg
- 97.27%
- TargetMol Chemicals Inc.