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Meclizine dihydrochloride

Meclizine dihydrochloride
Meclizine dihydrochloride structure
CAS No.
1104-22-9
Chemical Name:
Meclizine dihydrochloride
Synonyms
diadril;bonamine;NSC 28728;Navidoxine;Meclozine Hcl;)-4-(3-methyL;Meclizine 2HCl;Meclizine diHCl;Meclozine ,Bonamine;ancolandihydrochloride
CBNumber:
CB9362486
Molecular Formula:
C25H29Cl3N2
Formula Weight:
463.87
MOL File:
1104-22-9.mol

Meclizine dihydrochloride Properties

Melting point:
210.0 to 214.0 °C
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
form 
powder
color 
white to beige
CAS DataBase Reference
1104-22-9(CAS DataBase Reference)
EPA Substance Registry System
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride (1104-22-9)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H361
Precautionary statements  P281-P280-P301+P312+P330
Hazard Codes  Xn
Risk Statements  22-63
Safety Statements  22-36
WGK Germany  3
RTECS  TL2005000
Toxicity LD50 oral in mouse: 1600mg/kg

Meclizine dihydrochloride price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0950 Meclizine dihydrochloride ≥97% (HPLC) 1104-22-9 50mg $96.5 2021-12-16 Buy
Sigma-Aldrich M0220000 Meclozine dihydrochloride European Pharmacopoeia (EP) Reference Standard 1104-22-9 m0220000 $190 2021-12-16 Buy
Sigma-Aldrich M0220000 Meclozine dihydrochloride European Pharmacopoeia (EP) Reference Standard 1104-22-9 $190 2021-12-16 Buy
TCI Chemical M2755 Meclizine Dihydrochloride >98.0%(HPLC) 1104-22-9 5g $65 2021-12-16 Buy
TCI Chemical M2755 Meclizine Dihydrochloride >98.0%(HPLC) 1104-22-9 25g $195 2021-12-16 Buy

Meclizine dihydrochloride Chemical Properties,Uses,Production

Description

Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM). Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung. Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.

Chemical Properties

White or yellowish-white, slightly hygroscopic, crystalline powder.

Originator

Antivert,Roerig,US,1957

Uses

Meclizine Dihydrochloride is a histamine H1 receptor antagonist with antiemetic properties. Meclizine Dihydrochloride is a research product for neuroscience. This compound may exhibit neuroprotective properties.

Uses

Antiemetic;Histamine antagonist

Uses

cholinergic, diagnostic aid

Manufacturing Process

32.3 g of 1-p-chlorobenzhydryl-4-benzyl-piperazine, dissolved in 300 cm3 of alcohol are heated in an autoclave vessel, in the presence of Raney nickel, under a pressure of 100 kg H2, at about 150°C for 6 hours. The catalyst is filtered, the solvent is evaporated and the residue is fractionated under a high vacuum. p-Chlorobenzylhydryl-piperazine (BP 180° to 185°C/1 mm Hg) is isolated with a yield of 75%. Then finely ground NaNH2 is added. The mixture is heated under reflux for 1 hour, the mass is cooled and a molar equivalent of m-methyl benzyl chloride is added.
The solvent is evaporated and the residue is dissolved in chloroform. This solution is washed with a saturated solution of K2CO3 and dried on K2CO3. The solvent is evaporated and the residue is distilled under high vacuum. The product of the condensation distills near 230°C at 2 mm Hg pressure and the corresponding dihydrochloride melts at 217° to 224°C.

brand name

Antivert (Pfizer).

Therapeutic Function

Antinauseant

Biochem/physiol Actions

Meclizine has the ability to increase glycolysis and decrease cellular ATP levels in media that has glucose and galactose. It guards the kidney against ischemia-reperfusion injury. Meclizine is considered as an anti-nausea and anti-dizziness drug, was identified in a ′nutrient-sensitized′ chemical screen. In human, it acts as an agonist of pregnane X receptor (PXR). It enhances the expression of CYP3A4 (cytochrome P450 3A4) mRNA and reduces CYP3A-catalyzed testosterone 6β-hydroxylation in primary cultures of human hepatocytes.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cland NOx.

Meclizine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Meclizine dihydrochloride Suppliers

Global( 187)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15419 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
GIHI CHEMICALS CO.,LIMITED
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Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
HubeiwidelychemicaltechnologyCo.,Ltd
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Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
+86 15821988213 info@longyupharma.com China 2514 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63726 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com China 47498 58
career henan chemical co
15093356674 0371-55982848
0086-371-86658258 factory@coreychem.com CHINA 29863 58

View Lastest Price from Meclizine dihydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-20 Meclizine dihydrochloride
1104-22-9
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2021-07-13 Meclizine dihydrochloride
1104-22-9
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10 Meclizine dihydrochloride
1104-22-9
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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