3-(1,1-Difluorobut-3-en-1-yl)quinoxaline-2-ol
- CAS No.
- 2146141-67-3
- Chemical Name:
- 3-(1,1-Difluorobut-3-en-1-yl)quinoxaline-2-ol
- Synonyms
- 3-(1,1-Difluorobut-3-en-1-yl)quinoxaline-2-ol;2-chloro-3-(1,1-difluorobut-3-en-1-yl)quinoxaline;2(1H)-Quinoxalinone, 3-(1,1-difluoro-3-buten-1-yl)-
- CBNumber:
- CB94794102
- Molecular Formula:
- C12H10F2N2O
- Molecular Weight:
- 236.22
- MDL Number:
- MOL File:
- 2146141-67-3.mol
3-(1,1-Difluorobut-3-en-1-yl)quinoxaline-2-ol Chemical Properties,Uses,Production
Uses
3-(1,1-Difluorobut-3-en-1-yl)quinoxaline-2-ol can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
The DMF solution of 62 is heated to 80° C. to complete the Claisen rearrangement. Upon completion, the reaction is cooled to 0° C. A solution of benzene 1,2-diamine 18 (0.90 equiv) in DMF (7.5 mL) is sparged with nitrogen and then charged to the reaction maintaining a temperature below 25° C.; rinsing with DMF (2.5 mL) to complete the transfer. The temperature is adjusted to 20° C. and mixed until reaction completion. The temperature is adjusted to 40° C. and a 10 wt % aqueous ammonium chloride solution (95 mL) is slowly charged to crystallize the product 64. The slurry is cooled and filtered, washing the wet cake aqueous DMF and then water. The wet cake is dried to remove residual water. The crude product 64 can be recrystallized from toluene or toluene/heptane. The typical yield of 64 is 65%.
3-(1,1-Difluorobut-3-en-1-yl)quinoxaline-2-ol Preparation Products And Raw materials
Raw materials
Preparation Products
3-(1,1-Difluorobut-3-en-1-yl)quinoxaline-2-ol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huaian yishu technology co.,ltd | 86-0517-85883738 13852390259 | sales@yishuchem.com | CHINA | 53 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shanghai Rochi Pharmaceutical Co.,Ltd. | 21-38751876 +8615000076078 | info@rochipharma.com | China | 431 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| Nanjing Fred Technology Co., Ltd | +86-25-84696168 +86-15380713688 | Austin@fredbio.com | China | 2449 | 58 |
| Shanghai Rochi Pharmaceutical Co., Ltd. | 021-38751876 15000076078 | Info@rochipharma.com | China | 561 | 55 |
| Zhengzhou Acme Chemical Co., Ltd. | 0371-0371-55629727 13323845623 | 2885676761@qq.com | China | 9859 | 58 |
| Huaian yishu technology co.,ltd | 0517-85883738; 13852390259 | sales@yishuchem.com | China | 64 | 58 |
| Shanghai Neff Biotechnology Co., LTD | 14782051321 | market@lifebiology.cn | China | 147 | 58 |
| Wuhan Xinyang Ruihe Chemical Technology Co., Ltd. | 027-027-83850106 13720181483 | 366443693@QQ.COM | China | 3578 | 58 |
View Lastest Price from 3-(1,1-Difluorobut-3-en-1-yl)quinoxaline-2-ol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 3-(1,1-Difluorobut-3-en-1-yl)quinoxaline-2-ol
2146141-67-3
|
US $6.68 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
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- 3-(1,1-Difluorobut-3-en-1-yl)quinoxaline-2-ol
2146141-67-3
- US $6.68 / KG
- 97%-99%
- Career Henan Chemical Co