ChemicalBook >> CAS DataBase List >>AB 680)
AB 680)
- CAS No.
- 2105904-82-1
- Chemical Name:
- AB 680)
- Synonyms
- CD73 inhibitor AB-680;AB 680);AB680 ，S8908;AB680 (AB-680;AB-680, 10 mM in DMSO;Inhibitor,AB680,CD73,inhibit,AB 680,AB-680;1H-Pyrazolo[3,4-b]pyridin-4-amine, 6-chloro-N-[(1S)-1-(2-fluorophenyl)ethyl]-1-[5-O-[hydroxy(phosphonomethyl)phosphinyl]-β-D-ribofuranosyl]-;(((((2R,3S,4R,5R)-5-(6-Chloro-4-(((S)-1-(2-fluorophenyl)ethyl)amino)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid
- CBNumber:
- CB94844429
- Molecular Formula:
- C20H24ClFN4O9P2
- Molecular Weight:
- 580.83
- MDL Number:
- MFCD32062822
- MOL File:
- 2105904-82-1.mol
Last updated:2025-04-17 18:22:24
| Boiling point | 867.0±75.0 °C(Predicted) |
|---|---|
| Density | 1.86±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C, stored under nitrogen |
| solubility | DMSO : 200 mg/mL (344.34 mM; Need ultrasonic) |
| pka | 1.62±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| FDA UNII | J6K8WSV73A |
AB 680) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0090231 | AB-680 99.71% | 2105904-82-1 | 1mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0090231 | AB-680 99.71% | 2105904-82-1 | 5mg | $980 | 2021-12-16 | Buy |
| ChemScene | CS-0090231 | AB-680 99.71% | 2105904-82-1 | 10mg | $1500 | 2021-12-16 | Buy |
| DC Chemicals | DC21981 | CD73inhibitorAB-680 >98% | 2105904-82-1 | 1g | $3900 | 2021-12-16 | Buy |
| DC Chemicals | DC21981 | CD73inhibitorAB-680 >98% | 2105904-82-1 | 100mg | $950 | 2021-12-16 | Buy |
AB 680) Chemical Properties,Uses,Production
Uses
AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].
References
[1] Lawson KV, et al. Discovery and Characterization of AB680, a Potent and Selective Small-Molecule CD73 Inhibitor for Cancer Immunotherapy.
AB 680) Preparation Products And Raw materials
Raw materials
Preparation Products
AB 680) Suppliers
Global( 55)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32376 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39003 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shanghai Hanhong Scientific Co., Ltd. | +undefined17612118332 | Lucky@hanhonggroup.com | China | 6035 | 58 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 18971495150; | sales@sun-shinechem.com | China | 1047 | 64 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3479 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 | shenlinxing@macklin.cn | China | 15874 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4648 | 55 |
AB 680)
AB680
(AB-680
Inhibitor,AB680,CD73,inhibit,AB 680,AB-680
1H-Pyrazolo[3,4-b]pyridin-4-amine, 6-chloro-N-[(1S)-1-(2-fluorophenyl)ethyl]-1-[5-O-[hydroxy(phosphonomethyl)phosphinyl]-β-D-ribofuranosyl]-
(((((2R,3S,4R,5R)-5-(6-Chloro-4-(((S)-1-(2-fluorophenyl)ethyl)amino)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid
AB-680, 10 mM in DMSO
CD73 inhibitor AB-680
AB680 ，S8908
2105904-82-1
