BIBU1361 dihydrochloride (BIBU 1361 )
- CAS No.
- 1643609-75-9
- Chemical Name:
- BIBU1361 dihydrochloride (BIBU 1361 )
- Synonyms
- BIBU1361 dihydrochloride (BIBU 1361 )
- CBNumber:
- CB94844555
- Molecular Formula:
- C22H28Cl2FN7
- Molecular Weight:
- 480.41
- MDL Number:
- MOL File:
- 1643609-75-9.mol
BIBU1361 dihydrochloride (BIBU 1361 ) Chemical Properties,Uses,Production
Description
BIBU-1361 dihydrochloride is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase that blocks downstream EGFR signaling events such as MAPKK/MAPK activation.
Uses
BIBU 1361 Dihydrochloride, is a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). It also blocks downstream EGFR signaling events such as MAPKK/MAPK activation.
in vitro
BIBU (BIBU-1361) caused increased LC3-I to LC3-II conversion and triggered the internalization of EGFR within vacuoles along with its increased co-localization with LC3-II. BIBU caused accumulation of p62 and increased levels of cleaved forms of Beclin-1 in all the cell lines tested._x000D_ _x000D_ Reference: Mol Carcinog. 2013 Dec;52(12):970-82. https://pubmed.ncbi.nlm.nih.gov/22753156/
target
Selective inhibitor of EGFR-kinase.
BIBU1361 dihydrochloride (BIBU 1361 ) Preparation Products And Raw materials
Raw materials
Preparation Products
BIBU1361 dihydrochloride (BIBU 1361 ) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4191 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.com | China | 24246 | 58 |