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GSK840

GSK840 structure

CAS No.: 2361146-30-5

Chemical Name:: GSK840

Synonyms: GSK840;tert-butyl2-(4-(5-(methylcarbamoyl)-1H-benzo[d]im;tert-butyl 2-(4-(5-(methylcarbamoyl)-1H-benzo[d]imidazol-1-yl)phenyl)acetate;Inhibitor,RIP kinase,GSK 840,Receptor-interacting protein kinases,GSK840,inhibit,GSK-840,RIPK;Benzeneacetic acid, 4-[5-[(methylamino)carbonyl]-1H-benzimidazol-1-yl]-, 1,1-dimethylethyl ester

CBNumber:: CB95419747

Molecular Formula:: C21H23N3O3

Molecular Weight:: 365.43

MDL Number:

MOL File:: 2361146-30-5.mol

Last updated:2023-09-04 15:51:00

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GSK840 Properties

Density	1.18±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	110 mg/mL in DMSO
pka	14.16±0.46(Predicted)

GSK840 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	KIN0008618	GSK-840 95.00%	2361146-30-5	5MG	$458.27	2021-12-16	Buy

Product number	Packaging	Price	Buy
KIN0008618	5MG	$458.27	Buy

GSK840 Chemical Properties,Uses,Production

Biological Activity

GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, binds with high affinity to the RIP3 kinase domain with an IC50 of 0.9 nM, and inhibits kinase activity with an IC50 of 0.3 nM.

in vitro

GSK840 (GSK'840) (0.01-3 μM; 24 hours) blocks TNF-induced necroptosis in a concentration-dependent manner.
GSK840 binds the kinase domain and inhibits kinase activity with high specificity, targeting a broader range of pro-necrotic stimuli than can be achieved with RIP1 kinase inhibitors.

Cell Viability Assay

Cell Line:	Human HT-29 cells (TNF 10 ng/ml + zVAD-fmk 20 μM + SMAC007 100 nM)
Concentration:	0.01-3 μM
Incubation Time:	24 hours
Result:	Blocked TNF-induced necroptosis in a concentration-dependent manner.

target

IC50: 0.3 nM (RIP3)

GSK840 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK840 Suppliers

Global( 30)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42057	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9708	58
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 18892239720	psaitong@jm-bio.com	China	12308	58
Yujinpharma(Tianjin) Technology Co.,Ltd.	13370351217 kungfu1217@1	kungfu1217@163.com	China	9474	58

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Aladdin Scientific	58
Shanghai EFE Biological Technology Co., Ltd.	58
ShangHai Biochempartner Co.,Ltd	62
Beijing Jin Ming Biotechnology Co., Ltd.	58
Yujinpharma(Tianjin) Technology Co.,Ltd.	58

GSK840 Spectrum

GSK840(2361146-30-5)¹HNMR

GSK840 tert-butyl 2-(4-(5-(methylcarbamoyl)-1H-benzo[d]imidazol-1-yl)phenyl)acetate Inhibitor,RIP kinase,GSK 840,Receptor-interacting protein kinases,GSK840,inhibit,GSK-840,RIPK tert-butyl2-(4-(5-(methylcarbamoyl)-1H-benzo[d]im Benzeneacetic acid, 4-[5-[(methylamino)carbonyl]-1H-benzimidazol-1-yl]-, 1,1-dimethylethyl ester 2361146-30-5