MPT0B392
- CAS No.
- 1346169-92-3
- Chemical Name:
- MPT0B392
- Synonyms
- MPT0B392;MPT0B392,MPT-0B392;5-Quinolinamine, 6-methoxy-2-[(3,4,5-trimethoxyphenyl)sulfonyl]-
- CBNumber:
- CB95540388
- Molecular Formula:
- C19H20N2O6S
- Molecular Weight:
- 404.44
- MDL Number:
- MFCD32174244
- MOL File:
- 1346169-92-3.mol
MPT0B392 Chemical Properties,Uses,Production
Uses
MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line[1].
in vivo
The effects of MPT0B392 (oral gavage; 50 mg/kg or 100 mg/kg for 12 or 14 days) shows relative potent anti-leukemia activity in a vivo xenograft model[1].
| Animal Model: | Severe combined immunodeficient (SCID) mice [1] |
| Dosage: | 50 mg/kg or 100 mg/kg |
| Administration: | Oral gavage; 12 or 14 days |
| Result: | Resulted in significant tumor growth delay (83.3%) and tumor volume inhibition without loss of body weight. |
IC 50
JNK; Caspase
References
[1] Chao MW, et al. An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells. Oncotarget. 2017 Apr,8(17):27772-27785. DOI:10.18632/oncotarget.15115
MPT0B392 Preparation Products And Raw materials
Raw materials
Preparation Products
MPT0B392 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5002 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29257 | 58 |
| Adooq Bioscience LLC | 400-025-6535 | sales@adooq.cn | China | 6215 | 58 |
| Guangzhou Weisheng Biotechnology Co., Ltd. | 17765667235 | CHINA | 129 | 58 | |
| Shenzhen Zuoke Biotechnology Co., Ltd. | 13532174601 | CHINA | 109 | 58 |
