CS-003 Free base
- CAS No.
- 191672-52-3
- Chemical Name:
- CS-003 Free base
- Synonyms
- CS-003 Free base;CS 003 Free base,CS003 Free base;Methanone, [(2R)-2-(3,4-dichlorophenyl)-2-[2-[(2S)-2-oxidospiro[benzo[c]thiophene-1(3H),4'-piperidin]-1'-yl]ethyl]-4-morpholinyl](3,4,5-trimethoxyphenyl)-
- CBNumber:
- CB95821351
- Molecular Formula:
- C34H38Cl2N2O6S
- Molecular Weight:
- 673.65
- MDL Number:
- MFCD32197314
- MOL File:
- 191672-52-3.mol
| Boiling point | 846.5±65.0 °C(Predicted) |
|---|---|
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 8.69±0.20(Predicted) |
| FDA UNII | VGDEDKUKP2 |
CS-003 Free base Chemical Properties,Uses,Production
Biological Activity
CS-003 Free base (CS-003) is a tritachykinin receptor antagonist with high affinity for human neurokinin NK1, NK2 and NK3 receptors with Ki values of 2.3 nM and 0.54 nM, respectively and 0.74 nM.It can be used in the study of neurokinin-related respiratory diseases.
in vitro
CS-003 (0.01-10 μM; 24 hours) inhibits NK1, NK2 or NK3 induced inositol phosphate formation in a concentration-dependent manner with pA2 values of 8.7, 9.4 and 9.5 μM, respectively.
in vivo
CS-003 (intravenous injection; 0.01-3.0 mg/kg; 5 min before neurokinin A/B/C injection) inhibits substance P-induced tracheal vascular hyperpermeability, neurokinin A- and neurokinin B-induced bronchoconstriction with ID 50 values of 0.13, 0.040 and 0.063 mg/kg, respectively.
target
| NK1 2.3 nM (Ki) | NK2 0.54 nM (Ki) | NK3 0.74 nM (Ki) | < /table>
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10011 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 58 |
| cjbscvictory | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |