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BI-9321
- CAS No.
- 2387510-86-1
- Chemical Name:
- BI-9321
- Synonyms
- BI-9321;BI9321,BI 9321;Benzenemethanamine, 4-[5-(7-fluoro-4-quinolinyl)-1-methyl-1H-imidazol-4-yl]-3,5-dimethyl-
- CBNumber:
- CB98054329
- Molecular Formula:
- C22H21FN4
- Molecular Weight:
- 360.43
- MDL Number:
- MFCD34469296
- MOL File:
- 2387510-86-1.mol
Last updated:2023-03-13 11:54:02
BI-9321 Chemical Properties,Uses,Production
Biological Activity
BI-9321 is a potent, selective, and cellularly active NSD3-PWWP1 antagonist with a Kd of 166 nM. BI-9321 is not valid for NSD2-PWWP1 and NSD3-PWWP2. BI-9321 specifically disrupts the interaction of NSD3-PWWP1 with histones in U2OS cells with IC50 of 1.2 μM.
in vitro
BI-9321 is targeting the methyl-lysine binding site of the PWWP1 domain with sub-micromolar in vitro activity and cellular target engagement at 1 μM. As a single agent, BI-9321 downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells.
target
Kd: 166 nM (NSD3-PWWP1)
BI-9321 Preparation Products And Raw materials
Raw materials
Preparation Products
BI-9321 Suppliers
Global( 7)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3423 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Beijing Keyi Tongda Technology Development Co., Ltd | 13681252203 | kytd20@sina.com | China | 1285 | 58 |
BI-9321
BI9321,BI 9321
Benzenemethanamine, 4-[5-(7-fluoro-4-quinolinyl)-1-methyl-1H-imidazol-4-yl]-3,5-dimethyl-
2387510-86-1