ChemicalBook >> CAS DataBase List >>1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-
![1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Structure](CAS/20200611/GIF/2407829-65-4.gif)
- CAS No.
- 2407829-65-4
- Chemical Name:
- 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-
- Synonyms
- WUN-29654;CRBN modulator-1;CRBN modulator-1, 10 mM in DMSO;2-(2,6-Dioxo-3-piperidyl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione;2-(2,6-Dioxopiperidin-3-yl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione;1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-;3-(2,6-dioxopiperidin-3-yl)-7-hydroxy-3-azatricyclo[7.3.1.0?,13]trideca-1(13),5,7,9,11-pentaene-2,4-dione;3-(2,6-dioxopiperidin-3-yl)-11-hydroxy-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(13),5,7,9,11-pentaene-2,4-dione;CRBN modulator1,CRBN modulator-1,inhibit,CRBN modulator 1,Ligands for E3 Ligase,E3 ligase-recruiting Moiety,Inhibitor
- CBNumber:
- CB98096800
- Molecular Formula:
- C17H12N2O5
- Molecular Weight:
- 324.29
- MDL Number:
- MFCD33029299
- MOL File:
- 2407829-65-4.mol
Last updated:2025-04-17 18:22:24
| Product description | Number | Pack Size | Price |
| CRBNmodulator-1 >98% | DC42464 | 100mg | $750 |
| CRBNmodulator-1 >98% | DC42464 | 1g | $2900 |
| Boiling point | 680.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.587±0.06 g/cm3(Predicted) |
| solubility | DMSO : 10 mg/mL (30.84 mM; ultrasonic and adjust pH to 2 with HCl) |
| form | Solid |
| pka | 8.27±0.20(Predicted) |
| color | Light green to green |
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- price
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Chemical Properties,Uses,Production
Uses
CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM[1].
Biological Activity
CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM[1].
IC 50
Cereblon
References
[1]. Nathanael Gray, et al. New crbn modulators. WO2020006262A1.
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- Suppliers
Global( 42)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
| Shanxi Tihondan Pharmaceutical Technology Co., Ltd | +8618235132063 | sales@tihondan.com | China | 3767 | 58 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 7471 | 65 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4768 | 55 | |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4981 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-
WUN-29654
CRBN modulator-1
2-(2,6-Dioxopiperidin-3-yl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione
CRBN modulator1,CRBN modulator-1,inhibit,CRBN modulator 1,Ligands for E3 Ligase,E3 ligase-recruiting Moiety,Inhibitor
3-(2,6-dioxopiperidin-3-yl)-7-hydroxy-3-azatricyclo[7.3.1.0?,13]trideca-1(13),5,7,9,11-pentaene-2,4-dione
3-(2,6-dioxopiperidin-3-yl)-11-hydroxy-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(13),5,7,9,11-pentaene-2,4-dione
CRBN modulator-1, 10 mM in DMSO
2-(2,6-Dioxo-3-piperidyl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione
2407829-65-4
