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ChemicalBook >> CAS DataBase List >>1H-Benzimidazole, 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-6-(4-methyl-1-piperazinyl)-

1H-Benzimidazole, 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-6-(4-methyl-1-piperazinyl)-

1H-Benzimidazole, 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-6-(4-methyl-1-piperazinyl)- Structure
1H-Benzimidazole, 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-6-(4-methyl-1-piperazinyl)- structure
CAS No.
1627826-19-0
Chemical Name:
1H-Benzimidazole, 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-6-(4-methyl-1-piperazinyl)-
Synonyms
CPL304110;1H-Benzimidazole, 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-6-(4-methyl-1-piperazinyl)-
CBNumber:
CB98203143
Molecular Formula:
C25H30N6O2
Molecular Weight:
446.54
MDL Number:
MOL File:
1627826-19-0.mol
Last updated:2025-04-18 09:53:12
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1H-Benzimidazole, 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-6-(4-methyl-1-piperazinyl)- Properties

Boiling point 700.0±70.0 °C(Predicted)
Density 1.251±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (223.94 mM; Need ultrasonic)
pka 10.53±0.10(Predicted)
form Solid
color White to light yellow

1H-Benzimidazole, 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-6-(4-methyl-1-piperazinyl)- Chemical Properties,Uses,Production

Uses

CPL304110 is a potent, orally active and selective inhibitor of fibroblast growth factor receptors FGFR (1-3), with IC50 values of 0.75 nM, 0.5 nM, and 3.05 nM for FGFR (1-3), respectively[1].

in vivo

CPL304110 (p.o., 40 mg/kg) exhibits a t1/2 of 2 h and Cmax of 3369 ng/mL in mice[1].
CPL304110 (compound 56q, 2 X 20 mg/kg) significantly inhibits tumor growth in mice without significant body loss or any toxicity. On day 21 (D21, day of termination) the tumor growth inhibition (TGI) is 64% for dosing 20 mg/kg twice a day[1].

Animal Model:Severe combined immunodeficient (SCID) mice implanted subcutaneously with SNU-16 (human)[1].
Dosage:20 mg/kg (X2).
Administration:Orally, twice daily for 21 days.
Result:After 6 hours of last dosing, concentration of 56q decreased in the plasma (9%) but increased stepwise in the tumor cells (121%).

IC 50

FGFR1: 0.75 nM (IC50); FGFR2: 0.5 nM (IC50); FGFR3: 3.05 nM (IC50)

References

[1] Abdellah Yamani, et al. Discovery and optimization of novel pyrazole-benzimidazole CPL304110, as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1-3). Eur J Med Chem. 2020 Nov 7;112990. DOI:10.1016/j.ejmech.2020.112990

1H-Benzimidazole, 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-6-(4-methyl-1-piperazinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Benzimidazole, 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-6-(4-methyl-1-piperazinyl)- Suppliers

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Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
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Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5002 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
Supplier Advantage
Aladdin Scientific 		58
Jinan Jiuli Biotechnology Co. , Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
RD International Technology Co., Limited 58
1H-Benzimidazole, 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-6-(4-methyl-1-piperazinyl)- CPL304110 1627826-19-0