ChemicalBook >> CAS DataBase List >>3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione
3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione
![3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione Structure](CAS/20210111/GIF/2300099-98-1.gif)
- CAS No.
- 2300099-98-1
- Chemical Name:
- 3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione
- Synonyms
- E3 ligase Ligand 32;3-(5-bromo-3-methyl-2-oxo-benzimidazol-1-yl)piperidine-2,6-dione;3-(5-BROMO-3-METHYL-2-OXO-2,3-DIHYDRO-1H-BENZODIMIDAZOL-1-YL)PIPERIDINE-2;3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1-benzimidazolyl)piperidine-2,6-dione;2,6-Piperidinedione, 3-(5-bromo-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-;3-(5-bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione;3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)piperidine-2,6-dione;3-(5-Bromo-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-2,6-piperidinedione (ACI)
- CBNumber:
- CB98368488
- Molecular Formula:
- C13H12BrN3O3
- Molecular Weight:
- 338.16
- MDL Number:
- MOL File:
- 2300099-98-1.mol
Last updated:2025-04-17 18:22:24
| Boiling point | 533.3±50.0 °C(Predicted) |
|---|---|
| Density | 1.670±0.06 g/cm3(Predicted) |
| pka | 11.11±0.40(Predicted) |
| form | Solid |
| color | Off-white to light brown |
| InChI | InChI=1S/C13H12BrN3O3/c1-16-10-6-7(14)2-3-8(10)17(13(16)20)9-4-5-11(18)15-12(9)19/h2-3,6,9H,4-5H2,1H3,(H,15,18,19) |
| InChIKey | JTRNEHBIODAOTJ-UHFFFAOYSA-N |
| SMILES | N1C(=O)CCC(N2C(=O)N(C)C3=CC(Br)=CC=C32)C1=O |
3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione Chemical Properties,Uses,Production
Uses
E3 ligase Ligand 32 (First product in Example 52) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743)[1].
IC 50
VHL
References
[1] Nan Ji, et al. Smarca degraders and uses thereof. Worldwide applications 2020 US WO
3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione Preparation Products And Raw materials
Raw materials
Preparation Products
3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione Suppliers
Global( 44)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 20208 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
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| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39004 | 58 |
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| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 6576 | 65 |
| Bide Pharmatech Ltd. | 400-164-7117 13681763483 | product02@bidepharm.com | China | 42446 | 60 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9350 | 58 |
2,6-Piperidinedione, 3-(5-bromo-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-
3-(5-bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione
3-(5-bromo-3-methyl-2-oxo-benzimidazol-1-yl)piperidine-2,6-dione
3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1-benzimidazolyl)piperidine-2,6-dione
3-(5-Bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)piperidine-2,6-dione
3-(5-Bromo-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-2,6-piperidinedione (ACI)
3-(5-BROMO-3-METHYL-2-OXO-2,3-DIHYDRO-1H-BENZODIMIDAZOL-1-YL)PIPERIDINE-2
E3 ligase Ligand 32
2300099-98-1