BMS-986256
- CAS No.
- 2171019-55-7
- Chemical Name:
- BMS-986256
- Synonyms
- BMS-986256;Afimetoran（BMS-986256）;Afimetoran, 10 mM in DMSO;Toll-like Receptor (TLR),Afimetoran,BMS 986256,inhibit,BMS986256,Inhibitor;2-(4-(2-(7,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)acetamide;1-Piperidineacetamide, 4-[2-(7,8-dimethyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-(1-methylethyl)-1H-indol-5-yl]-;2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-(propan-2-yl)-1H-indol-5-yl)piperidin-1-yl)acetamide
- CBNumber:
- CB98381869
- Molecular Formula:
- C26H32N6O
- Molecular Weight:
- 444.57
- MDL Number:
- MOL File:
- 2171019-55-7.mol
| Density | 1.32±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO : 100 mg/mL (224.94 mM; ultrasonic and adjust pH to 2 with HCl) |
| pka | 15.19±0.30(Predicted) |
| form | Solid |
| color | White to off-white |
| FDA UNII | LXP7MZL0VF |
BMS-986256 Chemical Properties,Uses,Production
Uses
Afimetoran (BMS-986256) is an orally active, selective, and highly bioavailable TLR7/8 antagonist. Afimetoran (BMS-986256) can inhibit TLR7/8 activation of the NF-κB pathway and reverse TLR7 mediated resistance to steroid induced apoptosis in plasma cell like dendritic cells (pDCs). Afimetoran (BMS-986256) can be used for research on inflammation and autoimmune diseases (systemic lupus erythematosus)[1][2].
in vivo
Afimetoran (0.25 mg/kg; once daily; p.o.) shows strong therapeutic effects in late lupus mouse models by inhibiting the activation of TLR7/8[2].
| Animal Model: | NZB/W mice with advanced lupus (proteinuria > 100 mg/dL)[2]. |
| Dosage: | 0.25 mg/kg |
| Administration: | Oral gavage (p.o.); once daily |
| Result: | Reversed kidney tissue damage, proteinuria, the number of IgG positive glomeruli, and the deposition of IgG in glomeruli, and reduced cytokine secreting cells and cytokines, resulting in a nearly complete (92%) survival rate. |
IC 50
TLRs
References
[1] Zhao Q, et al. POS1129 IN VITRO EVIDENCE DEMONSTRATES THAT AFIMETORAN (BMS-986256), AN EQUIPOTENT TLR7/8 DUAL ANTAGONIST, HAS STEROID-SPARING POTENTIAL IN THE CLINIC[J]. 2023.
[2] Dudhgaonkar S, et al. PO. 1.1 Afimetoran, a potent and selective inhibitor of human toll-like receptor 7 (TLR7) and tlr8, provides robust efficacy in a murine lupus model of advanced disease[J]. 2022.
BMS-986256 Preparation Products And Raw materials
Raw materials
Preparation Products
BMS-986256 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Shanghai XingMo Biotechnology Co., Ltd. | +86 13524779951; 13524779951 | 2075692521@qq.com | China | 310 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4757 | 55 | |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2390 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
View Lastest Price from BMS-986256 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-05 | Afimetoran
2171019-55-7
|
US $84.00-328.00 / mg | 99.81% | 10g | TargetMol Chemicals Inc. |
-
- Afimetoran
2171019-55-7
- US $84.00-328.00 / mg
- 99.81%
- TargetMol Chemicals Inc.
