ChemicalBook >> CAS DataBase List >>Pregna-1,4-diene-3,20-dione-4,6,11,12,12-d5, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16β)-

Pregna-1,4-diene-3,20-dione-4,6,11,12,12-d5, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16β)-

Pregna-1,4-diene-3,20-dione-4,6,11,12,12-d5, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16β)- structure

CAS No.: 2244574-92-1

Chemical Name:: Pregna-1,4-diene-3,20-dione-4,6,11,12,12-d5, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16β)-

Synonyms: Pregna-1,4-diene-3,20-dione-4,6,11,12,12-d5, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16β)-

CBNumber:: CB99930235

Molecular Formula:: C22H29FO5

Molecular Weight:: 392.47

MDL Number:

MOL File:: 2244574-92-1.mol

Last updated:2025-08-21 14:05:29

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Pregna-1,4-diene-3,20-dione-4,6,11,12,12-d5, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16β)- Properties

solubility	DMSO: Soluble Methanol: Soluble

Pregna-1,4-diene-3,20-dione-4,6,11,12,12-d5, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16β)- Chemical Properties,Uses,Production

Uses

Betamethasone-d5-1 is deuterium labeled Betamethasone. Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Schwab M, et, al. Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol. 2000 Nov 1;528(Pt 3):619-32. DOI:10.1111/j.1469-7793.2000.00619.x
[3] Xie W, et, al. Betamethasone affects cerebral expressions of NF-kappaB and cytokines that correlate with pain behavior in a rat model of neuropathy. Ann Clin Lab Sci. Winter 2006;36(1):39-46. PMID:16501235
[4] Kubin ME, et, al. Clinical Efficiency of Topical Calcipotriol/Betamethasone Treatment in Psoriasis Relies on Suppression of the Inflammatory TNFα - IL-23 - IL-17 Axis. Acta Derm Venereol. 2017 Apr 6;97(4):449-455. DOI:10.2340/00015555-2579
[5] Hofmann TH, et, al. Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription. FEBS Lett. 1998 Dec 28;441(3):441-6. DOI:10.1016/s0014-5793(98)01609-3
[6] M. CORBEL. Comparative Effects of Betamethasone, Cyclosporin and Nedocromil Sodium in Acute Pulmonary Inflammation and Metalloproteinase Activities in Bronchoalveolar Lavage Fluid from Mice Exposed to Lipopolysaccharide[J]. Pulmonary pharmacology & therapeutics, 1999, 12 3: Pages 165-171. DOI: 10.1006/pupt.1999.0178
[7] JOHANNES VAN DER MERWE MD , PHD Jan D M, PHD. Neurocognitive sequelae of antenatal corticosteroids in a late preterm rabbit model[J]. American journal of obstetrics and gynecology, 2022, 226 6: Pages 850.e1-850.e21. DOI: 10.1016/j.ajog.2021.11.1370
[8] JOSE GALAZ. Betamethasone as a potential treatment for preterm birth associated with sterile intra-amniotic inflammation: a murine study.[J]. Journal of Perinatal Medicine, 2021, 49 7: 897-906. DOI: 10.1515/jpm-2021-0049

Pregna-1,4-diene-3,20-dione-4,6,11,12,12-d5, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16β)- Preparation Products And Raw materials

Raw materials

Preparation Products

Pregna-1,4-diene-3,20-dione-4,6,11,12,12-d5, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16β)- Suppliers

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Shanghai isotope chemical co.,ltd	021-51600108 13062666369	sales@isotopechem.com	China	5000	58
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Cayman Chemical Company	800-364-9897	sales@caymanchem.com	China	6838	58

Supplier	Advantage
Shanghai isotope chemical co.,ltd	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
Cayman Chemical Company	58

Pregna-1,4-diene-3,20-dione-4,6,11,12,12-d5, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16β)- 2244574-92-1