Betaine
- CAS No.
- 107-43-7
- Chemical Name:
- Betaine
- Synonyms
- TRIMETHYLGLYCINE;Betain;Glycine betaine;BET;Methanaminium;Abromine;LYCINE;NMF-50;N-TRIMETHYLGLYCINE HYDROXIDE;HSB1214
- CBNumber:
- CB0760102
- Molecular Formula:
- C5H11NO2
- Molecular Weight:
- 117.15
- MOL File:
- 107-43-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/31 17:33:32
| Melting point | 310 °C (dec.) |
|---|---|
| Boiling point | 218.95°C (rough estimate) |
| Density | 1.00 g/mL at 20 °C |
| vapor pressure | 0.05Pa at 25℃ |
| refractive index | 1.4206 (estimate) |
| FEMA | 4223 | BETAINE |
| storage temp. | 2-8°C |
| solubility | methanol: 0.1 g/mL, clear |
| form | Crystals or Crystalline Powder |
| pka | 1.83(at 0℃) |
| color | colorless |
| Odor | bland |
| Water Solubility | 160 g/100 mL |
| Sensitive | Hygroscopic |
| Merck | 14,1179 |
| BRN | 3537113 |
| Stability | Stable. Hygroscopic. Incompatible with strong oxidizing agents. |
| InChIKey | KWIUHFFTVRNATP-UHFFFAOYSA-N |
| LogP | -3.1 at 20℃ |
| CAS DataBase Reference | 107-43-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Methanaminium, 1-carboxy-n,n,n-trimethyl-, hydroxide, inner salt(107-43-7) |
| EPA Substance Registry System | Betaine (107-43-7) |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xn | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DS5900000 | |||||||||
| F | 3-10 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29239000 | |||||||||
| NFPA 704 |
|
Betaine price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W422312 | Betaine ≥98% | 107-43-7 | 1SAMPLE-K | ₹4113.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W422312 | Betaine ≥98% | 107-43-7 | 1KG | ₹22992.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W422312 | Betaine ≥98% | 107-43-7 | 5KG | ₹46244.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B2629 | Betaine ≥98% (perchloric acid titration) | 107-43-7 | 50G | ₹2890.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B2629 | Betaine ≥98% (perchloric acid titration) | 107-43-7 | 100G | ₹5206.83 | 2022-06-14 | Buy |
Betaine Chemical Properties,Uses,Production
Chemical Properties
White cryst. powder
Uses
betaine is a surfactant, humectant, and excellent skin conditioner. It is also used to build product viscosity and as a foam booster. It is found mostly in skin cleansers, shampoos, and bath products.
Definition
ChEBI: The amino acid betaine derived from glycine.
General Description
Betaine also called trimethylglycine or N,N,N triethylammonium acetate, is an analog of glycine with three methyl groups. It is highly compatible with polymerase chain reaction (PCR) buffer mixture. Betaine is a PCR enhancing reagent that is widely used for improving the yield and specificity of PCR products, especially during the PCR amplification of targets rich in GC content or those that form secondary structures resulting in poor yield. Betaine facilitates DNA strand separation and manages the DNA melting temperature (Tm) difference between the GC and AT pairs in DNA. It stabilizes the ds DNA by equalizing the contribution of GC- and AT-base pairs. Betaine has been broadly used to optimize multiplex and ‘long and accurate′ polymerase chain reaction (LA-PCR). The addition of 1.0-1.7 M aqueous betaine to a PCR mixture has been reported to reduce the base pair composition dependence on DNA strand melting.
Purification Methods
Crystallise betaine from aqueous EtOH or EtOH/Et2O. The monohydrate loses H2O above 100o. Betaine undergoes internal alkylation to methyl dimethylaminoacetate Purification of Biochemicals — Amino Acids and Peptides above its melting point. It is also prepared by treating the hydrochloride (below) with silver oxide and recrystallising from EtOH/Et2O. [Edsall J Am Chem Soc 66 1767 1943, Leifer & Lippincott J Am Chem Soc 79 5098 1957, for pK see Grob et al. Chem and Ind (London) 1222 1955, Beilstein 4 III 1127, 4 IV 2369.]
Betaine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jeevan Chemicals and Pharmaceuticals | +91-9820112971 +91-9326362295 | Maharashtra, India | 44 | 58 | Inquiry |
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Unicorn Petroleum Industries Private Limited | +91-2225299990 +91-9930731710 | Maharashtra, India | 22 | 58 | Inquiry |
| Nuray Chemicals Pvt Ltd | +91-4066616700 +91-8220444745 | Tamil Nadu, India | 49 | 58 | Inquiry |
| Suvan LifeSciences (formerly Sansh Biotech Pvt Ltd) | +91-1142631798 +91-9899000024 | New Delhi, India | 55 | 58 | Inquiry |
| Molkem Chemicals Pvt. Ltd. | 91-79-61202500 | Gujarat, India | 199 | 58 | Inquiry |
| HRV Global Life Sciences Private Limited | 91-40-23554991 | Hyderabad, India | 190 | 58 | Inquiry |
| Dovoy Chemicals India Private Limited | Haryana, India | 3 | 58 | Inquiry | |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| MSC Chemicals | 08069013895Ext 494 | Karnataka, India | 38 | 58 | Inquiry |
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