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Bendamustine hydrochloride

Bendamustine hydrochloride Structure
CAS No.
3543-75-7
Chemical Name:
Bendamustine hydrochloride
Synonyms
EP3101;Treanda;SDX 105;DD6304600;CYTOSTASAN;Ribomustin;ZIMET-33/93;Cytostasane;Bendamustina;CytostasanHCl
CBNumber:
CB0777896
Molecular Formula:
C16H22Cl3N3O2
Molecular Weight:
394.72
MOL File:
3543-75-7.mol
Modify Date:
2025/7/24 18:13:48

Bendamustine hydrochloride Properties

Melting point 149-151°C
storage temp. room temp
solubility H2O: >30mg/mL
form powder
color off-white
Merck 14,1034
InChI InChI=1S/C16H21Cl2N3O2.ClH/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H
InChIKey ZHSKUOZOLHMKEA-UHFFFAOYSA-N
SMILES C12N=C(CCCC(=O)O)N(C)C=1C=CC(N(CCCl)CCCl)=C2.Cl
CAS DataBase Reference 3543-75-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06,GHS08
Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Signal word  Danger
Hazard statements  H301-H341-H351-H361fd
Hazard statements  H301-H341-H351-H361fd
Precautionary statements  P201-P202-P264-P270-P280-P301+P310
Precautionary statements  P201-P202-P264-P270-P280-P301+P310
Hazard Codes  T,Xn
Risk Statements  60-61-22-40
Safety Statements  36-37
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
RTECS  DE1590000
HazardClass  6.1
PackingGroup  III
HS Code  29339900
Toxicity LD50 (monohydrate) in mice, rats (mg/kg): 400-500, 200-300 orally; 80, 40 i.v. (Horn)
NFPA 704
0
2 0

Bendamustine hydrochloride price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) B5437 Bendamustine hydrochloride hydrate ≥98% (HPLC) 3543-75-7 5MG ₹15328.2 2022-06-14 Buy
Sigma-Aldrich(India) B5437 Bendamustine hydrochloride hydrate ≥98% (HPLC) 3543-75-7 25MG ₹61258.68 2022-06-14 Buy
Product number Packaging Price Buy
B5437 5MG ₹15328.2 Buy
B5437 25MG ₹61258.68 Buy

Bendamustine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Pale Brown Crystals

Uses

Bendamustine hydrochloride hydrate has been used as:

  • a chemotherapy agent for chronic lymphocytic leukemia (CLL) samples to monitor spliced and unspliced gene expression
  • an inhibitor to E3 ubiquitin-protein ligase RNF3 (HOIP) in?matrix-assisted laser desorption ionization time-of-flight mass spectrometry?(MALDI-TOF) assay
  • a cytotoxic chemotherapeutic drug in high-throughput screening to test interaction with BAY87-2243

General Description

Bendamustine comprises 2-chloroethylamine alkylating group, a butyric acid side chain and a benzimidazole ring in its structure and is a nitrogen mustard. It is catabolized in the liver by the enzyme cytochrome P450 1A2 into γ hydroxyl-bendamustine and N-desmethyl-bendamustine.

Biological Activity

Cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.

Global( 451)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Dr. Reddy's Laboratories Ltd +91-4049002900 Hyderabad, India 165 58 Inquiry
SGMR PHARMACEUTICALS PVT LTD +91-9032001889 Telangana, India 83 58 Inquiry
Shree HariKrishna Pharmaceuticals +91-9925611910 Gujarat, India 16 58 Inquiry
Aavyan Labs +91-9652399498 Telangana, India 60 58 Inquiry
Salvavidas Pharmaceutical Pvt., Ltd. +91-2612538898 +91-9327127459 Gujarat, India 34 58 Inquiry
Basil Drugs AND Pharmaceuticals Pvt Ltd +91-2249700250 +91-9619320820 Mumbai, India 108 58 Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd. +91-26463395 +91-7926462688 Gujarat, India 1615 58 Inquiry
Sakar Healthcare +91-8976292690 +91-9967572302 Gujarat, India 47 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
Shivalik Rasayan Ltd +91-1147589500 +91-9811043611 New Delhi, India 12 58 Inquiry

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