ChemicalBook > Product Catalog >API >Hormones and the Endocrine System >Estrogen and progestin drugs >Ethisterone

Ethisterone

Ethisterone Structure
CAS No.
434-03-7
Chemical Name:
Ethisterone
Synonyms
Progestoral;17A-ETHYNYLTESTOSTERONE;Prone;Pranone;Pregnin;Gestoral;NSC-9565;Prodoxan;Produxan;Prolutol
CBNumber:
CB1207877
Molecular Formula:
C21H28O2
Molecular Weight:
312.45
MOL File:
434-03-7.mol
Modify Date:
2023/11/2 15:05:42

Ethisterone Properties

Melting point 263-269 °C (lit.)
alpha D23 +23.8° (dioxane); D25 -32.0° (pyridine)
Boiling point 392.36°C (rough estimate)
Density 1.0697 (rough estimate)
refractive index 33 ° (C=1, Pyridine)
storage temp. room temp
solubility Soluble to 0.05 mg/mL (0.16 mM) in DMSO
pka 13.10±0.60(Predicted)
Water Solubility soluble in chloroform, DMSO (0.05 mg/ml), acetone (slightly ), ethanol (<1 mg/ml at 25°C), and water (<1 mg/ml at 25°C).
Merck 14,3741
BRN 1889895
InChIKey CHNXZKVNWQUJIB-CEGNMAFCSA-N
CAS DataBase Reference 434-03-7
NIST Chemistry Reference Ethisterone(434-03-7)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08,GHS09
Signal word  Danger
Hazard statements  H360FD-H410
Precautionary statements  P201-P202-P273-P280-P308+P313-P391
Hazard Codes  Xn,T
Risk Statements  40-48-61
Safety Statements  22-24/25-45-53
RIDADR  UN 2811
WGK Germany  3
RTECS  TU5570250
HS Code  29372390

Ethisterone price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) E1001 Ethisterone ≥99% (HPLC) 434-03-7 25G ₹24486.15 2022-06-14 Buy
Sigma-Aldrich(India) E1001 Ethisterone ≥99% (HPLC) 434-03-7 100G ₹78968.38 2022-06-14 Buy
Product number Packaging Price Buy
E1001 25G ₹24486.15 Buy
E1001 100G ₹78968.38 Buy

Ethisterone Chemical Properties,Uses,Production

Description

Ethisterone is an orally bioavailable synthetic progestin and a derivative of testosterone (Item Nos. ISO60154 | 15645) that binds to progesterone and androgen receptors (EC50s = 23 and 23.1 nM, respectively, in yeast). Ethisterone (1 μM) downregulates progesterone receptors in MCF-7 cells.

Chemical Properties

Off-White Powder

Uses

Ethisterone has been used as a component in Dulbecco′s modified eagle medium (DMEM) to culture the transfected COS-7 cell for transient transfection assay and?gene transfection assay.

Definition

ChEBI: A 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.

General Description

Ethisterone is a?progestogen. It is a danazol derivative.

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4,17ALPHA-PREGNEN-17BETA-OL-20-YN-3-ONE 4,17a-pregnen-17b-ol-20-yn-3-one 4,17A-PREGNEN-17B-OL-20-YNE 4-ANDROSTEN-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE (8R,9S,10R,13S,14S,17R)-17-ETHYNYL-17-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE ANHYDROHYDROXYPROGESTERONE ANHYDROXYPROGESTERONE 17BETA-HYDROXY-4,17ALPHA-PREGNEN-20-YN-3-ONE 17b-hydroxy-4,17a-pregnen-20-yn-3-one (8R,9S,10R,13S,14S,17S)-17-ethynyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one 17A-ETHYNYL-4-ANDROSTEN-17B-OL-3-ONE 17a-ethynyl-17b-hydroxy-4-androsten-3-one 17ALPHA-ETHYNYLTESTOSTERONE 17α-Ethynyltestosterone, 17β-Hydroxy-4,17α-pregnen-20-yn-3-one, 4,17α-Pregnen-17β-ol-20-yn-3-one (8R,9S,10R,13S,14S,17R)-17-ETHYNYL-17-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHY ETHISTERONE(RG) Ethisterone,17α-Ethynyltestosterone, 17β-Hydroxy-4,17α-pregnen-20-yn-3-one, 4,17α-Pregnen-17β-ol-20-yn-3-one ETHISTERONE(RG)(CALL) Ethisterone 0 (17α)-17-hydroxy-pregn-4-en-20-yn-3-one ETHINYL TESTOSTERONE ETHISTERONE ETHYNYLTESTOSTERONE ETHYNYLANDROSTENOLONE (17-alpha)-pregn-4-en-20-yn-3-on Gestoral Lucorteum Oral lucorteumoral Lutidon Oral lutidonoral Lutocyclin Lutocyclol Lutocylol Nalutoral NSC-9565 Nugestoral Ora-Lutin Pranone Pregn-4-en-20-yn-3-one, 17-hydroxy-, (17alpha)- Pregneninolone Pregnin Primolut C primolutc Prodoxan Prodroxan Produxan Progestab Progestin P progestinp Progestolets Prolutol Proluton C 17-alpha-ethinyltestosterone 17alpha-Ethynyl-17beta-hydroxyandrost-4-en-3-one 17alpha-Pregn-4-en-20-yn-3-one, 17-hydroxy- 17-beta-Hydroxy-17-alpha-ethynyl-4-androsten-3-one 17-Ethinyltestosterone 17-Ethynyl-17beta-hydroxyandrost-4-en-3-one