MGluR5 inhibitor
- CAS No.
- 871362-31-1
- Chemical Name:
- MGluR5 inhibitor
- Synonyms
- CTEP;CS-1999;RO4956371;CTEP (RO4956371);MGluR5 inhibitor;CTEP, 10 mM in DMSO;MGluR5 inhibitor(CTEP);MGluR5 inhibitor USP/EP/BP;Metabotropic glutamate receptors,CTEP,RO4956371,inhibit,mGluR,Inhibitor,RO-4956371;2-chloro-4-[2-[2,5-dimethyl-1-[4-(trifluoromethoxy)phenyl]imidazol-4-yl]ethynyl]pyridine
- CBNumber:
- CB72645136
- Molecular Formula:
- C19H13ClF3N3O
- Molecular Weight:
- 391.77
- MOL File:
- 871362-31-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/9/18 19:10:02
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H320-H335 |
| Precautionary statements | P264-P270-P301+P312-P330 |
MGluR5 inhibitor price More Price(2)
MGluR5 inhibitor Chemical Properties,Uses,Production
Biochem/physiol Actions
CTEP is a high-affinity, orally active, potent and selective metabotropic glutamate receptor 5 (mGlu5 or mGluR5) negative allosteric modulator (NAM) and inverse agonist (human/mouse/rat mGlu5 Kd = 1.7/1.8/1.5 nM; IC50 against quisqualate stimulation = 6.4/16.8/8/8 by IP accumulation or 11.4/42/4/6.9 by Ca2+ mobilization using human/mouse/rat mGlu5 HEK293 transfectants; IC50 = 40.1 nM against constitutive IP level in human mGlu5 HEK293) with >1000-fold selectivity over 103 molecular targets, including all known mGluRs. CTEP is an excellent tool compound for long-term in vivo studies (in mice and rats) with good pharmacokinetic properties (B/P ratio = 2.6, oral bioavailability ~100%, T1/2 ~18 hrs post 4.5 mg/kg p.o. in mice) and reported to display 30- to 100-fold higher in vivo potency than MPEP and fenobam in two rodent behavioral models sensitive to antianxiety drugs.
MGluR5 inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 33024 | 60 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5743 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | United States | 32434 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30229 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 20342 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | China | 10473 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6391 | 58 | Inquiry |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | China | 24727 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354; | United States | 39031 | 58 | Inquiry |
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