プロメタジン塩酸塩 化学特性,用途語,生産方法
外観
白色～うすい黄色, 粉末
溶解性
水に易溶、エタノール,クロロホルムに可溶。水に極めて溶けやすく、エタノールに溶けやすい。
用途
フェノチアジン誘導体です。
抗ヒスタミン作用を示します。
用途
神経化学研究用。
効能
抗アレルギー薬, 制吐薬, パーキンソン病治療薬, H1受容体拮抗薬
商品名
ヒベルナ (田辺三菱製薬); ヒベルナ (田辺三菱製薬)
使用上の注意
光によって徐々に着色する。
化学的特性
White Solid
使用
Promethazine hydrochloride is used as antihistamine; antiemetic; central nervous system depressant; sedative; anticholinergic; antiserotoninergic; local anesthetic;
in the treatment of motion sickness, cough linctuses, nausea, and allergic conditions; used to control Parkinsonian symptoms and as
central nervous system depressant; in pills, syrup, injections and suppositories.
定義
ChEBI: The hydrochloride salt of promethazine.
一般的な説明
Odorless white to faint yellow crystalline powder. Bitter taste. A 10% solution in water has a pH of 3.5-5.0.
空気と水の反応
Slowly oxidizes in air, acquiring a blue color. Also turns blue on exposure to moisture. Water soluble.
反応プロフィール
Promethazine hydrochloride is sensitive to light. In aqueous solution, Promethazine hydrochloride is degraded by heat and light (more rapidly in air or oxygen). Incompatible with alkalis and alkaline solutions such as those of aminophylline, soluble barbiturates and phenytoin sodium. Iron(III) and copper(III) accelerate the degradation .
火災危険
Flash point data for Promethazine hydrochloride are not available; however, Promethazine hydrochloride is probably combustible.
安全性プロファイル
Poison by ingestion,
subcutaneous, intraperitoneal, and
intravenous routes. Human systemic effects
by ingestion: excitement, sleep, convulsions,
rigdity. Experimental teratogenic effects.
Other experimental reproductive effects.
When heated to decomposition it emits very
toxic fumes of HCl, SOx, and NOx. Used as
an antihstamine.
プロメタジン塩酸塩 上流と下流の製品情報
原材料
準備製品