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トポテカン塩酸塩

トポテカン塩酸塩 化学構造式
119413-54-6
CAS番号.
119413-54-6
化学名:
トポテカン塩酸塩
别名:
トポテカン塩酸塩;ノギテカン塩酸塩;ノギテカン塩酸塩 (JAN)
英語化学名:
Topotecan hydrochloride
英語别名:
108563;Hycamtin;NSC 609669;SKF-104864A;Levulan-13C;SKFS 104864A;TOPOTECAN HCL;HYDROCHLORIDE;Nogitecan HCl;5-ALA HCl-13C
CBNumber:
CB3361775
化学式:
C23H24ClN3O5
分子量:
457.91
MOL File:
119413-54-6.mol

トポテカン塩酸塩 物理性質

融点 :
213-218°C
貯蔵温度 :
Refrigerator
外見 :
Light yellow to greenish powder.
CAS データベース:
119413-54-6(CAS DataBase Reference)

安全性情報

主な危険性  T
Rフレーズ  25-36/37/38-46
Sフレーズ  26-36/37/39-45
HSコード  29420000

トポテカン塩酸塩 価格 もっと(16)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CAY14129
Topotecan (hydrochloride)
119413-54-6 10mg ¥7800 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01CAY14129
Topotecan (hydrochloride)
119413-54-6 5mg ¥5500 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01LKTT5761 トポテカン
Topotecan
119413-54-6 1mg ¥7500 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01LKTT5761 トポテカン
Topotecan
119413-54-6 5mg ¥11200 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01LKTT5761 トポテカン
Topotecan
119413-54-6 10mg ¥13500 2018-12-26 購入

トポテカン塩酸塩 化学特性,用途語,生産方法

効能

抗悪性腫瘍薬, トポイソメラーゼI阻害薬

商品名

ハイカムチン (日本化薬)

化学的特性

White Crystalline Solid

使用

Naturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme. Antineoplastic (photosensitizer)

使用

antineoplastic; topoisomerase I inhibitor

使用

A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Topotecan hydrochloride is a chemotherapy agent that is a topoisomerase 1 inhibitor.

brand name

Topotecan is INN and BAN.

一般的な説明

Topotecan is supplied in 4-mg vials and administered IV forthe treatment of ovarian cancer, cervical cancer, and smallcell lung cancer in those patients who did not respond tofirst-line therapy. Following IV administration, the drug iswidely distributed with 10% to 35% of the agent bound toplasma proteins. There is evidence that the agent may crossthe blood-brain barrier to some extent. In plasma, an equilibriumis established between the lactone and the less activehydroxy acid with 20% of the drug present as the lactone 1hour after the infusion is complete. In contrast to irinotecan,both the lactone and the hydroxy acid bind equally well tohuman serum albumin. N-Demethylation of the tertiaryamine to give the secondary amine is mediated by CYP3A4and represents a minor route of metabolism. Glucuronidationof the parent and the phase I metabolites also occurs to a limited(10%) extent.Elimination occurs primarily in theurine, with 30% of the dose being recovered as unchangeddrug. The terminal elimination half-life is 2 to 3 hours. Themajor toxicity seen for topotecan is dose-limiting myelosuppression.Nausea and vomiting are seen in most (70%–80%)patients, along with diarrhea and abdominal pain. Other toxicitiesinclude headache myalgias, alopecia and elevation ofserum transaminases, alkaline phosphatases, and bilirubin.Microscopic hematuria (blood in the urine) may also be seen.

薬物動態学

Topotecan elimination is biphasic, with a terminal half-life of 2.0 to 3.5 hours. Lactone hydrolysis is rapid, and binding to serum proteins is limited to between 25 and 40%. CYP3A4-mediated N-dealkylation to mono?and didealkylated metabolites occurs to a limited extent, and the O-glucuronides that form at multiple points along the metabolic path are excreted via the kidney.

臨床応用

This active camptothecin analogue is used by the IV route in the treatment of ovarian and small cell lung cancer that has not responded to first-line therapy.

トポテカン塩酸塩 上流と下流の製品情報

原材料

準備製品


トポテカン塩酸塩 生産企業

Global( 325)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21838 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Chengdu GLP Biotech Co., Ltd
13350802083
scglp@glp-china.com CHINA 1008 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2645 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58

119413-54-6(トポテカン塩酸塩)キーワード:


  • 119413-54-6
  • {3-[4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-pyrazol-1-yl]-azetidin-3-yl}-acetonitrile
  • 4-(2-Oxo-butyl)-benzamidine
  • Topotecan (Nogitecan) hydrochloride
  • TOPOTECAN MONOHYDROCHLORIDE
  • TOPOTECAN HCL
  • SKF-104864A
  • HYDROCHLORIDE
  • topetecan hydrochloride
  • 5-PIPERAZIN-1-YL-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER
  • 9-[(DIMETHYLAMINO)METHYL]-10-HYDROXY-(20S)-CAMPTOTHECIN, HCL
  • (4S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4',6-7]INDOLIZINO[1,2-B]QUINOLINE-3,14(4H,12H)-DIONE
  • (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, Hydrochloride, SKF-104864A,
  • (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Hydrochloride
  • 1,4-di[4-(3-phenoxypropoxy)-2-butynyl]piperazine
  • 1,4-di(4-benzhydryloxy-2-butynyl)piperazine
  • 1,4-di(4-benzyloxy-2-butynyl)piperazine
  • (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-(H-Pyrano[3' , 4':6,7]indolizino[1,2-b]quinoline-3,14[4H,12H]-dione monohydrochloride
  • Topotecan Hydrochloride(TPT)
  • S-(6-thioxo-1,6-dihydro-pyrimidin-4-yl)-isothiourea
  • Topotecan hydrochloride(NSC-609699)
  • Topotecan, Hydrochloride Salt
  • Toputecan hydrochloride
  • 2-Methyl-4-piperidino-butan-2-ol
  • Topotecan HCl (HycaMtin)
  • 3-Methoxy-5-Methyl-4-MethylaMino-heptanoic acid tert-butyl ester
  • [2-(4-Methyl-piperazin-1-yl)-ethyl]-carbamic acid tert-butyl ester
  • Topotecan hydrocloride
  • Topotecan (Nogitecan) HCl
  • (3,5-Dimethoxy-phenyl)-(1H-pyrazol-3-ylmethyl)-amine
  • (2S)-2-[[(2R)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanamide
  • トポテカン塩酸塩
  • ノギテカン塩酸塩
  • ノギテカン塩酸塩 (JAN)
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