Milbemycin oxime
Milbemycin oxime 物理性質
- 融点 :
- 169.6-177.4°
- 闪点 :
- 412℃
- 貯蔵温度 :
- Store at -20°C
- 溶解性:
- DMSO:100.0(Max Conc. mg/mL);91.13(Max Conc. mM)
- 外見 :
- A crystalline solid
- 安定性：:
- Hygroscopic
- InChIKey:
- LKMMLHTWKLEARD-MGZQXKBQSA-N
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| RIDADR |
2588 |
|
|
| WGK Germany |
3 |
|
|
| 国連危険物分類 |
6.1(b) |
|
|
| 容器等級 |
III |
|
|
| HSコード |
2932206000 |
|
|
| 毒性 |
LD50 orally in mice: 1000-1500 mg/kg (Ciba-Geigy) |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H410 |
長期的影響により水生生物に非常に強い毒性 |
水生環境有害性、慢性毒性 |
1 |
警告 |
|
P273, P391, P501 |
|
| 注意書き |
| P273 |
環境への放出を避けること。 |
| P391 |
漏出物を回収すること。 |
| P501 |
内容物/容器を．．．に廃棄すること。 |
|
Milbemycin oxime 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
Sigma-Aldrich Japan
|
PHR2633 |
certified reference material, pharmaceutical secondary standard
Milbemycin oxime certified reference material, pharmaceutical secondary standard |
129496-10-2 |
500MG |
￥41100 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
1443806 |
United States Pharmacopeia (USP) Reference Standard
Milbemycin oxime United States Pharmacopeia (USP) Reference Standard |
129496-10-2 |
200mg |
￥55400 |
2024-03-01 |
購入 |
Milbemycin oxime 化学特性,用途語,生産方法
使用
Milbemycin oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of two natural products, milbemycin A3 and A4 (in ~30:70 ratio). Milbemycin oxime is used therapeutically for the prevention of intestinal parasites in dogs. Like the other milbemycin/avermectins, it was developed for intestinal parasite control in animals and acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.
臨床応用
Milbemycin oxime (Milbemycin) is available as an oral chewable tablet (2.3–27 mg) for heartworm prevention in dogs and cats, as well as a 0.1% otic solution for treating ear mites. It is not available in a more concentrated dosage form, so overdoses are relatively rare[1].
Veterinary Drugs and Treatments
Milbemycin tablets are labeled as a once-a-month heartworm
preventative (Dirofilaria immitis) and for hookworm control
(Ancylostoma caninum). It has activity against a variety of other
parasites, including adult hookworms (A. caninum), adult roundworms
(T. canis, T. leonina) and whipworms (Trichuris vulpis). In
cats, milbemycin has been used successfully to prevent larval infection
of Dirofilaria immitis.
Milbemycin, like ivermectin can be used for treatment of generalized
demodicosis in dogs, but treatment can be significantly more
expensive. It is likely safer to use in breeds susceptible to mdr1 genetic
mutation (Collies, Shelties, Australian shepherds, etc.) at the
doses used for this indication, but neuro toxicity is possible. Older
dogs, those that have had a long duration of disease prior to treatment,
and dogs with pododemodicosis appear have a lower success
rate with milbemycin treatment.
Milbemycin oxime 上流と下流の製品情報
原材料
準備製品
Milbemycin oxime 生産企業
Global( 280)Suppliers
129496-10-2()キーワード:
- 129496-10-2
- Milbemycin oxime
- Milbemycin Oxime (200 mg)
- Milbemycin oxime CRS
- Milbemycin Oxime (Mixture of Milbemycin Oxime A3 and A4)
- Milbemycin OximeQ: What is
Milbemycin Oxime Q: What is the CAS Number of
Milbemycin Oxime Q: What is the storage condition of
Milbemycin Oxime
- Milbemycin Oxime (1443806)
- β-phenylacrylophenone
- Milbemite
- Sodium Pyrithione 3811-73-2
- Milbemycin, oxime (9CI, ACI)
- Mibemycin oxime
- Milbemycin Oxime (Mixture of Milbemycin Oxime A3 and Milbemycin Oxime A4, 20:80)