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ペラムパネル

ペラムパネル 化学構造式
380917-97-5
CAS番号.
380917-97-5
化学名:
ペラムパネル
别名:
ペラムパネル;ペランパネル
英語化学名:
PeraMpanel
英語别名:
E 2007;CS-1116;Perampane;PeraMpanel;ER 155055-90;PeraMpanel-D5;PERAMPANEL API;PeraMpanel-13C6;Perampanel(E2007);Perampanel Impurity
CBNumber:
CB12598797
化学式:
C23H15N3O
分子量:
349.38
MOL File:
380917-97-5.mol

ペラムパネル 物理性質

沸点 :
619.1±55.0 °C(Predicted)
比重(密度) :
1.31±0.1 g/cm3(Predicted)
酸解離定数(Pka):
4.73±0.19(Predicted)
CAS データベース:
380917-97-5

安全性情報

ペラムパネル 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCP285520 ペラムパネル
Perampanel
380917-97-5 10mg ¥35000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCP285520 ペラムパネル
Perampanel
380917-97-5 100mg ¥280000 2018-12-26 購入

ペラムパネル 化学特性,用途語,生産方法

効能

抗てんかん薬, AMPA受容体拮抗薬

説明

In October 2012, the US FDA approved perampanel for the treatment of partial onset seizures in epileptic patients who are at least 12 years old. Perampanel is the first AMPA receptor antagonist to receive FDA approval as an AED. AMPA glutamate receptors are found primarily on postsynaptic neurons in the brain. As a selective, noncompetitive antagonist of AMPA, parampanel prevents ion channel opening and reduces propagation of action potential. Parampanel was discovered through lead optimization of a commercially available compound, 2,4-diphenyl-4H-[1,3,4]oxadiazin-5-one, which was identified by high-throughput screening of a compound collection employing a rat cortical neuron AMPA-induced cell-death assay. Modifications of aromatic rings at positions 1, 3, and 5 while changing the core to pyridone led to parampanel which inhibited AMPA-induced calcium influx (IC50=60 nM). Parampanel had a minimum effective oral dose of 2 mg/kg in an AMPA-induced mouse seizure model. The synthesis of parampanel was accomplished via a 6-step route utilizing Suzuki–Miyaura couplings and modified Ullmann reactions for incorporation of aryl groups.

Originator

Eisai (Japan)

定義

ChEBI: A member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy.

brand name

Fycompa

ペラムパネル 上流と下流の製品情報

原材料

準備製品


ペラムパネル 生産企業

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380917-97-5(ペラムパネル)キーワード:


  • 380917-97-5
  • 3-(2-Cyanophenyl)-1-phenyl-5-(2-pyridyl)-1,2-dihydropyridin-2-one
  • 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
  • 2-(2-oxo-1-phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile
  • 2-(6'-Oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile
  • Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)-
  • ER 155055-90 Perampanel
  • Perampane
  • 2-(2-oxo-1-phenyl-5-pyridin-2- ylpyridin-3-yl)benzonitrile
  • Perampane,Perampanel Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)
  • PeraMpanel
  • E 2007
  • ER 155055-90
  • PeraMpanel-D5
  • PeraMpanel-13C6
  • CS-1116
  • E 2007; ER 155055-90; E-2007; E2007
  • Perampanel(E2007)
  • Perampanel/D3-labelled (3R,4R)-1-Benzyl-N,4-dimethylpiperidine-3-amine dihydrochloride
  • PERAMPANEL API
  • Perampanel Impurity 8
  • PeraMpanel fandachem
  • Perampanel Impurity
  • ペラムパネル
  • ペランパネル
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