STF31
|
|
|
- CAS番号.
- 724741-75-7
- 化学名:
- STF31
- 别名:
- STF31
- 英語名:
- STF 31
- 英語别名:
- STF 31;CS-1575;STF31;STF 31;N'-(4-METHYLPHENYL)-4-PYRIDINECARBOXIMIDAMIDE;4-((4-(tert-Butyl)phenylsulfonamido)methyl)-N-(pyridin-3-yl)benzamide; 4-[[(4-tert-butylphenyl)sulfonylamino]methyl]-N-pyridin-3-ylbenzamide;4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-benzamide;Benzamide, 4-[[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-;VHL,inhibitor,RCC4/VHL,STF31,Autophagy,STF 31,STF-31,GLUT,Glucose transporter,GLUT1,inhibit,glucose,RCC4
- CBNumber:
- CB12663075
- 化学式:
- C23H25N3O3S
- 分子量:
- 423.53
- MOL File:
- 724741-75-7.mol
- MSDS File:
- SDS
|
STF31 物理性質
- 比重(密度) :
- 1.247±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- -20°C
- 溶解性:
- DMSO：可溶20mg/mL、透明
- 酸解離定数(Pka):
- 11.28±0.50(Predicted)
- 外見 :
- 粉
- 色:
- 白からベージュ
- 安定性：:
- -20°C の DMSO 溶液で最大 1 か月間保存できます。
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 主な危険性 |
Xn |
|
|
| Rフレーズ |
22 |
|
|
| Sフレーズ |
46 |
|
|
| WGK Germany |
3 |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
|
| 注意書き |
|
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC4484 |
STF31
STF 31 |
724741-75-7 |
10mg |
￥79000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC4484 |
STF31
STF 31 |
724741-75-7 |
50mg |
￥332000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1108 |
≥98% (HPLC)
STF-31 ≥98% (HPLC) |
724741-75-7 |
5mg |
￥24800 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1108 |
≥98% (HPLC)
STF-31 ≥98% (HPLC) |
724741-75-7 |
25mg |
￥101000 |
2024-03-01 |
購入 |
STF31 化学特性,用途語,生産方法
説明
Glucose transporter 1 (Glut1) is an inducible carrier of pentoses and hexoses, including glucose. STF-31 is an inhibitor of Glut1 (IC
50 = ~1 μM) that blocks glucose uptake. It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene, which overexpress Glut1. Although STF-31 binds Glut1, suggesting a direct effect, STF-31 also inhibits nicotinamide phosphoribosyltransferase, an enzyme that induces Glut1 expression. STF-31 is also toxic to human pluripotent stem cells (hPSCs) and can be used to selectively eliminate hPSCs from mixed cultures.
使用
STF 31 is used in biological studies as pyridylanilinothiazoles and pyridylphenylsulfonyl benzamides scaffolds use to prepare affinity chromatoraphy reagents for cancer targeting. STF 31 is an inhibitor of GLUT1 which blocks glucose uptake.
Biochem/physiol Actions
STF-31 selectively inhibits the glucose transporter GLUT1 and selectively impairs cancer cell growth of kidney and other types of cancer cells that lack the von Hippel-Lindau (VHL) tumor suppressor protein. Inactivation of VHL increases the activity of hypoxia-inducible factor transcription factor HIF, which in turn stimulates the transcription of genes involved in glucose metabolism, including the GLUT1 gene. VHL-deficient cancer cells, which include about 80% of renal cell carcinomas, are dependent on the high affinity GLUT1 transporter and aerobic glycolysis for ATP production. STF-31 binds directly to the GLUT1 transporter, blocking glucose uptake, resulting in necrosis in VHL-deficient cancer cells, but not in normal cells or cancer cells with intact VHL.
STF31 上流と下流の製品情報
原材料
準備製品
STF31 生産企業
Global( 103)Suppliers
724741-75-7(STF31)キーワード:
- 724741-75-7
- STF 31
- 4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-benzamide
- N'-(4-METHYLPHENYL)-4-PYRIDINECARBOXIMIDAMIDE
- 4-[[(4-tert-butylphenyl)sulfonylamino]methyl]-N-pyridin-3-ylbenzamide
- STF31;STF 31
- CS-1575
- Benzamide, 4-[[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-
- 4-((4-(tert-Butyl)phenylsulfonamido)methyl)-N-(pyridin-3-yl)benzamide
- VHL,inhibitor,RCC4/VHL,STF31,Autophagy,STF 31,STF-31,GLUT,Glucose transporter,GLUT1,inhibit,glucose,RCC4
- STF31