1-(ピペリジン-1-イル)-1-(フェニル)シクロヘキサン 化学特性,用途語,生産方法
使用
Anesthetic.
定義
ChEBI: A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.
一般的な説明
Phencyclidine was introduced as a dissociative anestheticfor animals. Its close structural relative ketamine is still soused and may be used in humans. In humans,PCP produces a sense of intoxication, hallucinogenic experiencesnot unlike those produced by the anticholinergic hallucinogens,and often, amnesia.
The drug affects many systems, including those of NE,DA, and 5-HT. It has been proposed that PCP (and certainother psychotomimetics) produces a unique pattern of activationof ventral tegumental area dopaminergic neurons.Itblocks glutaminergic N-methyl-D-aspartate receptors.Thisaction is the basis for many of its CNS effects. PCP itself appearsto be the active agent. The psychotic state produced bythis drug is also cited as a better model than amphetaminepsychosis for the psychotic state of schizophrenia.
薬理学
PCP acts as a biocide through its ability
to uncouple mitochondrial oxidative phosphorylation.
安全性プロファイル
Poison by intraperitoneal route. Experimental reproductive effects. Caution: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.12 (1985). The ethylamine, pyrrolidine and thiophene analogs are l
代謝経路
When mice and rats are administered phencyclidine
intraperitoneally, several hydroxylated metabolites are
identified in the urine. A new metabolite, 1-phenyl-1-
(1-piperidinyl-3-ol)cyclohexane, is identified in the urine
and liver microsomal preparations.
代謝
Pentachlorophenolwas metabolized in rats
by conjugation with glucuronic acid and eliminated as
the glucuronide. P450 catalyzed oxidative dechlorination
also occurred to form tetrachlorohydroquinone, and this
was conjugated to form a monoglucuronide representing
27% of the dose administered. Other metabolites
have been reported, including isomeric tetrachlorophenols,
tetrachlorocatechol and tetrachlororesorcinol. Trace
amounts of benzoquinones were also noted.
Metabolites in female rats were tetrachloromonophenols,
diphenols, and hydroquinones.
1-(ピペリジン-1-イル)-1-(フェニル)シクロヘキサン 上流と下流の製品情報
原材料
準備製品