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L-アスパラギナーゼ

L-アスパラギナーゼ 化学構造式
9015-68-3
CAS番号.
9015-68-3
化学名:
L-アスパラギナーゼ
别名:
L-アスパラギナーゼ;アスパラギナーゼ 大腸菌由来
英語化学名:
ASPARAGINASE
英語别名:
CL059;mk-965;elspar;LASPAR;leunase;paronal;l-asnase;colaspase;crasnitin;kidrolase
CBNumber:
CB2484567
化学式:
C14H17NO4S
分子量:
295.35
MOL File:
Mol file

L-アスパラギナーゼ 物理性質

比旋光度 :
D20 -30 to -32°
貯蔵温度 :
2-8°C
外見 :
suspension
Merck :
13,841
CAS データベース:
9015-68-3
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T,Xn
Rフレーズ  61-42/43-63
Sフレーズ  53-22-36/37/39-45-36/37
RIDADR  3249
WGK Germany  3
RTECS 番号 CI9000000
10-21
国連危険物分類  6.1(a)
容器等級  II
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H317 アレルギー性皮膚反応を起こすおそれ 感作性、皮膚 1 警告 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H361 生殖能または胎児への悪影響のおそれの疑い 生殖毒性 2 警告 P201, P202, P281, P308+P313, P405,P501
注意書き
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

L-アスパラギナーゼ 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan A3809 アスパラギナーゼ 大腸菌由来 lyophilized powder, 100-300?units/mg protein (biuret)
Asparaginase from Escherichia coli lyophilized powder, 100-300?units/mg protein (biuret)
9015-68-3 100un ¥36000 2018-12-25 購入
Sigma-Aldrich Japan A3809 アスパラギナーゼ 大腸菌由来 lyophilized powder, 100-300?units/mg protein (biuret)
Asparaginase from Escherichia coli lyophilized powder, 100-300?units/mg protein (biuret)
9015-68-3 1ku ¥160600 2018-12-25 購入

L-アスパラギナーゼ 化学特性,用途語,生産方法

用途

製造用剤

説明

Using the enzyme asparaginase (L-asparagine amidohydrolase, EC 3.5.1.1), it is possible to significantly reduce the formation of the cooking carcinogen acrylamide during roasting, deep-frying, or baking of foods. The enzyme hydrolyzes free asparagine to aspartic acid, thereby preventing the formation of acrylamide by reaction of asparagine with reducing sugars at elevated temperatures during the Maillard reaction.
The mitigation of acrylamide formation is especially important for a number of cereal- and potato-based products, including crackers, crispbread, gingerbread, biscuits, French fries, and potato chips. After asparaginase pretreatment, the acrylamide concentration of certain foods could be reduced by up to 97 % [84, 86]. By means of in vitro directed evolution, the properties of asparaginase were optimized. For example, an Asp133Leu mutation of a wild-type enzyme showed a significantly improved thermal stability. The enzyme’s half-life at 50 C increased from 3 to 160 h, and the half-inactivation temperature of the mutant was 9 C higher.

Originator

Enzon (U.S.A.)

使用

Antineoplastic.

定義

An enzyme used in the treatment of certain types of leukemia. Produced by biochemical activity of certain bacteria, yeasts, and fungi. Yields are in excess of 3500 units/g of source.

適応症

The enzyme L-asparaginase (Elspar) is derived from the bacteria Escherichia coli and Erwinia carotovora. It catalyzes the hydrolysis of L-asparagine to aspartic acid and ammonia. L-Glutamine also can undergo hydrolysis by this enzyme, and during therapy, the plasma levels of both amino acid substrates fall to zero.Tumor cells sensitive to L-asparaginase are deficient in the enzyme asparagine synthetase and therefore cannot synthesize asparagine. Depletion of exogenous asparagine and glutamine inhibits protein synthesis in cells lacking asparagine synthetase, which leads to inhibition of nucleic acid synthesis and cell death.

brand name

Crasnitin (Bayer); Elspar (Merck);Oncaspar.

一般的な説明

Asparaginase is available in 10-mL vials for intramuscularand IV use in the treatment of acute lymphocytic leukemia.
Tumor cells are unable to synthesize asparagine, and thereforemust utilize what is available in the extracellular environment.The agent acts by hydrolyzing extracellular asparagineto aspartate and ammonia. The tumor cells are then deprivedof a necessary nutrient, and protein synthesis is inhibited leadingto cell death. The agent is specific for the G1 phase of thecell cycle. Resistance occurs because of the development ofthe tumor cells ability to produce asparagine synthetase thatallows them to synthesize the required amino acid. Antibodyproduction directed at asparaginase may be stimulated by theagent as well. The agent remains in the extracellular spaceafter parental administration and is 30% protein bound. Themetabolism of the agent has not been well characterized andthe plasma half-life depends on the formulation of the drug.The E. coli-derived agent has a plasma half-life of 40 to 50hours, whereas polyethylene glycol-asparaginase’s half-life is3 to 5 days. Adverse effects include hypersensitivity reactions,fever, chills, nausea, lethargy, confusion, hallucinations,and possibly coma. Myelosuppression is not generallyseen. An increased risk of bleeding and clotting is seen in halfof the patients taking the agent.

生物学的応用

L-asparaginase (EC. 3.5.1.1; asparagine amidohydrolase) catalyzes the hydrolysis of L-Asparagine to L-aspartic acid and ammonia. This enzyme is used for the treatment of selected types of hemopoietic diseases such as acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphomas (Pieters et al. 2011; Rytting 2012). It is also a model enzyme for the development of new drug delivery system and L-asparagine biosensor for leukemia. This enzyme was used in the food industry for the production of acrylamide free food (Kumar and Verma 2012; Dhanam Jayam and Kannan 2013).
Y. lipolytica is a potential producer of L-asparaginase. However, there are very few reports on L-asparaginase production by the yeast. Karanam and Medicherla optimized L-asparaginase production of Y. lipolytica NCIM 3472 in solid-state fermentation (SSF) using palm kernel cake as the substrate. The maximum L-asparaginase activity at optimum conditions was near 40 U/g of the initial dry substrate (U/gds) (Karanam and Medicherla 2010).

作用機序

The half-life of L-asparaginase in human plasma is 6 to 30 hours.The drug remains primarily in the intravascular space, so its volume of distribution is only slightly greater than that of the plasma. Metabolism and disposition are thought to occur through serum proteases, the reticuloendothelial system, and especially in patients with prior exposure to the drug, binding by antibodies. The drug is not excreted in urine, and very little appears in the CSF.

臨床応用

The major indication for L-asparaginase is in the treatment of acute lymphoblastic leukemia; complete remission rates of 50 to 60% are possible. Lack of crossresistance and bone marrow toxicity make the enzyme particularly useful in combination chemotherapy. LAsparaginase also can be used in the treatment of certain types of lymphoma. It has no role in the treatment of nonlymphocytic leukemias or other types of cancer.

臨床応用

Pegaspargase, a polyethylene glycol conjugate of L-asparaglnase (ASNase), was launched for combination chemotherapy in acute lymphoblastic leukemia (ALL). L-Asparaginase is an enzyme that inhibits protein synthesis by the depletion of sources of L-asparagine, which is necessary for transformed lymphoid cells to proliferate. It has been used as a standard component of the antileukemia armamentarium for childhood All. Pegaspargase has greater antitumor activity, a longer plasma half-life and less immunogenicity than ASNase. It produces minimal side effects after repeated dosing, whereas ASNase induces anaphylactic shock, urticaria, anorexia or vomiting and acute pancreatitis in dogs, and other immunological effects in man resulting from sensitization to the enzyme or protein synthesis inhibition. The efficacy of pegaspargase for other indications including breast and lung cancers, non-Hodgkin's lymphoma and pancreatic cancer has been reported.

抗がん研究

Both the commonly known and distinctive species have been reported to produceL-asparaginase. The common species of endophytes, which produce L-asparaginase,include Fusarium sp., Penicillium sp., and Colletotrichum sp. They are isolated asendophytes from a variety of medicinal plants (Audipudi et al. 2014; El-Said et al.2016).
Chow and Ting (2015) studiedL-asparaginase production from fungal endophytes isolated from anticancer plantsin Malaysia. They found Fusarium oxysporum and Penicillium simplicissimumfrom Murraya koenigii and Pereskia bleo, respectively, as effective producers ofL-asparaginase. In addition to L-asparaginase, endophytes from anticancer plantshave also been established as producers of other valuable anticancer, antimicrobial,and antioxidant compounds. This is further supported by many reports on discoveryof these anticancer agents in different species of endophytic fungi either from sameor different host plants.

副作用

Since it is a foreign protein, L-asparaginase may produce hypersensitivity reactions, including urticarial skin rashes and severe anaphylactic reactions. One-third of patients have nausea, anorexia, weight loss, and mild fever. Almost all patients develop elevated serum transaminases and other biochemical indices of hepatic dysfunction. Severe hepatic toxicity occurs in fewer than 5% of cases. Patients receiving L-asparaginase may develop symptoms of CNS toxicity, including drowsiness, confusion, impaired mentation, and even coma. Pancreatitis occurs in 5 to 10% of cases.Hyperglycemia, possibly due to inhibition of insulin synthesis, also may occur. L-Asparaginase differs from most cytotoxic drugs in its lack of toxicity to bone marrow, gastrointestinal tract, and hair follicles.

L-アスパラギナーゼ 上流と下流の製品情報

原材料

準備製品


L-アスパラギナーゼ 生産企業

Global( 65)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21909 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20653 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23982 58
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1943 70
Tianjin heowns Biochemical Technology Co., Ltd. 400 638 7771
sales@heowns.com China 14464 57
ShangHai YuanYe Biotechnology Co., Ltd. 021-61312847 qq:2797782341
021-55068248 2797782341@qq.com China 7215 60
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12343 58
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969
020-39119999 isunpharm@qq.com, isunpharm@hotmail.com China 5020 55
Nanjing Sunlida Biological Technology Co., Ltd. 025-58378339;025-57798810
025-57019371 sales@sunlidabio.com China 3823 55

9015-68-3(L-アスパラギナーゼ)キーワード:


  • 9015-68-3
  • l-asparaginasi
  • leunase
  • mk-965
  • nsc-109229
  • paronal
  • re82-tad-15
  • EC 3.5.1.1
  • L-asparginase
  • ASPARAGINASE FROM ESCHERICHIA COLISOLUTI ON IN GLYC
  • L-ASPARAGINASE FROM E. COLI &
  • ASPARAGINASE FROM ESCHERICHIA COLICHROMA TOGRAPHICA
  • ASPARAGINASE GRADE V FROM ESCHERICHIA CO
  • L-ASPARAGINASE FROM E. COLI, SUSPENSION, ~80 U/MG PROT.
  • asparaginase from escherichia coli
  • colaspase
  • crasnitin
  • elspar
  • kidrolase
  • l-asnase
  • l-asparaginasex
  • L-Asparaginase from Escherichia coli
  • Crasnitin Elspar
  • kisrolase
  • L-asparagise amidohydrolase
  • Asparaginase (usan 8ci 9ci)
  • Asparaginase, L- (escherichia coli)
  • L-ASPARAGINE AMIDOHYDROLASE
  • L-ASPARAGINASE
  • IUB: 3.5.4.4
  • ASPARAGINASE
  • L-アスパラギナーゼ
  • アスパラギナーゼ 大腸菌由来
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