(1aR,3S,4S,6Z,9S,15bR)-1a,8,9,15b-テトラヒドロ-3,4,12-トリヒドロキシ-9-メチル-14-メトキシ-3H-オキシレノ[k][2]ベンゾオキサシクロテトラデシン-5,11(2H,4H)-ジオン

(1aR,3S,4S,6Z,9S,15bR)-1a,8,9,15b-テトラヒドロ-3,4,12-トリヒドロキシ-9-メチル-14-メトキシ-3H-オキシレノ[k][2]ベンゾオキサシクロテトラデシン-5,11(2H,4H)-ジオン 価格 もっと(3)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
Sigma-Aldrich Japan	H1667	ヒポテマイシン from Hypomyces trichothecoides, ≥98% (HPLC) Hypothemycin from Hypomyces trichothecoides, ≥98% (HPLC)	76958-67-3	250μg	￥27500	2024-03-01	購入
Sigma-Aldrich Japan	H1667	ヒポテマイシン from Hypomyces trichothecoides, ≥98% (HPLC) Hypothemycin from Hypomyces trichothecoides, ≥98% (HPLC)	76958-67-3	1mg	￥100000	2024-03-01	購入
Sigma-Aldrich Japan	H1667	ヒポテマイシン from Hypomyces trichothecoides, ≥98% (HPLC) Hypothemycin from Hypomyces trichothecoides, ≥98% (HPLC)	76958-67-3	250ug	￥41700	2018-12-25	購入

(1aR,3S,4S,6Z,9S,15bR)-1a,8,9,15b-テトラヒドロ-3,4,12-トリヒドロキシ-9-メチル-14-メトキシ-3H-オキシレノ[k][2]ベンゾオキサシクロテトラデシン-5,11(2H,4H)-ジオン 化学特性,用途語,生産方法

使用

Hypothemycin is a potent and selective inhibitor of threonine/tyrosine-specific kinase, MEK, and other protein kinases that contain a conserved cysteine residue in the ATP-binding site in in vitro studies.

一般的な説明

A cell-permeable cis-enone resorlic acid lactone (RAL) and (5Z)-7-Oxozeaenol (Cat. No. 499610) analog that inhibits several kinases via an initial affinity binding to the ATP pocket, followed by a covalent adduct formation with a conserved ATP site cysteine residue of the targeted enzymes, including, but not limited to, Flt1/VEGFR-1, Flt3, cKit(D816V), MAPK1, MAPK2, MEK1, MKK6, PKCμ, PKD2, PRAK, and Tak1 (≥90% inhibition at 2 μM). Hypothemycin is also reported to inhibit two non-RAL targets (99% and 82% inhibition of TrkA and TrkB, respectively, at 2 μM), while one of the 46 putative cis-enone RALs targets, namely GSK-3α, is shown not to be affected. Hypothemycin inhibits multiple kinases involved in MAP kinase pathways and is therefore particularly effective in inhibiting BRAF(V600E)-dependent tumor growth. (5Z)-Zeaenol (Cat. No. 499609) may serve as a negative control.

Biochem/physiol Actions

Hypothemycin, one of the highly oxygenated analogues in the group of 14-membered resorcylic acid lactones (RAL), has minor antifungal and cytotoxic activity and exhibits an in vitro anti-malarial activity with an IC50 of 2.2 μg/mL. Hypothemycin is also reported to selectively and irreversibly inhibit protein kinases that contain a conserved cysteine residue (Cys166) that is located within the ATP-binding domain. Though this group accounts for less then 10% of all identified kinases, there are several targets implicated in aberrant cellular proliferation such as ERKs, MEK, FMS-like tyrosine kinase protein (FLT), and platelet-derived growth factor receptors (PDGFR). In cell culture, hypothemycin displays potent cytotoxicity against cancer cell lines that are dependent on certain activating kinase mutations. Additionally, hypothemycin demonstrates significant tumor growth inhibition in at least three separate murine xenograft models. Hypothemycin also inhibits the production of several cytokines such as IL2, IL6, IFNγ, and TNFα.

(1aR,3S,4S,6Z,9S,15bR)-1a,8,9,15b-テトラヒドロ-3,4,12-トリヒドロキシ-9-メチル-14-メトキシ-3H-オキシレノ[k][2]ベンゾオキサシクロテトラデシン-5,11(2H,4H)-ジオン 上流と下流の製品情報

原材料

準備製品

(1aR,3S,4S,6Z,9S,15bR)-1a,8,9,15b-テトラヒドロ-3,4,12-トリヒドロキシ-9-メチル-14-メトキシ-3H-オキシレノ[k][2]ベンゾオキサシクロテトラデシン-5,11(2H,4H)-ジオン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai Tauto Biotech Co., Ltd.	021-51320588	tauto@tautobiotech.com	China	3989	66
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2784	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	United Kingdom	4381	58
Shenzhen Regent Biochemical Technology Co., Ltd.	0755-0755-85201366 18938635012	sales@regentsciences.com	China	9288	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58

76958-67-3((1aR,3S,4S,6Z,9S,15bR)-1a,8,9,15b-テトラヒドロ-3,4,12-トリヒドロキシ-9-メチル-14-メトキシ-3H-オキシレノ[k][2]ベンゾオキサシクロテトラデシン-5,11(2H,4H)-ジオン)キーワード:

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• 76958-67-3
• HYPOTHEMYCIN
• (1aR,3S,4S,6Z,9S,15bR)-1a,2,4,5,11,8,9,15b-Octahydro-3,4,12-trihydroxy-9-methyl-14-methoxy-3H-oxireno[k][2]benzoxacyclotetradecin-5,11-dione
• (1aR,3S,4S,6Z,9S,15bR)-1a,8,9,15b-Tetrahydro-3,4,12-trihydroxy-9-methyl-14-methoxy-3H-oxireno[k][2]benzoxacyclotetradecin-5,11(2H,4H)-dione
• Hypothemicin
• Nsc354462
• 3H-Oxireno[k][2]benzoxacyclotetradecin-5,11(2H,4H)-dione,1a,8,9,15b-tetrahydro-3,4,12-trihydroxy-14-methoxy-9-methyl-,(1aR,3S,4S,6Z,9S,15bR)-
• (1aR,3S,4S,6Z,9S,15bR)-1a,8,9,15b-Tetrahydro-3,4,12-trihydroxy-14-methoxy-9-methyl-3H-oxireno[k][2]benzoxacyclotetradecin-5,11(2H,4H)-dione
• f 152 D2
• Hypothemycin - CAS 76958-67-3 - Calbiochem
• ヒポテミシン
• ヒポテマイシン
• (1aR,3S,4S,6Z,9S,15bR)-1a,8,9,15b-テトラヒドロ-3,4,12-トリヒドロキシ-9-メチル-14-メトキシ-3H-オキシレノ[k][2]ベンゾオキサシクロテトラデシン-5,11(2H,4H)-ジオン
• (1aR,3S,4S,6Z,9S,15bR)-1a,2,4,5,11,8,9,15b-オクタヒドロ-3,4,12-トリヒドロキシ-9-メチル-14-メトキシ-3H-オキシレノ[k][2]ベンゾオキサシクロテトラデシン-5,11-ジオン
• (2R,4R,6S,7S,9Z,12S)-6,7,16-トリヒドロキシ-18-メトキシ-12-メチル-3,13-ジオキサトリシクロ[13.4.0.02,4]ノナデカ-1(19),9,15,17-テトラエン-8,14-ジオン