S0859
S0859 物理性質
- 沸点 :
- 748.5±70.0 °C(Predicted)
- 比重(密度) :
- 1.313±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO：可溶10mg/mL、透明
- 外見 :
- 粉
- 酸解離定数(Pka):
- -1.34±0.40(Predicted)
- 色:
- 白から薄茶色
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
|
| 注意書き |
| P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
| P305+P351+P338 |
眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
|
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQJ-3550 |
2-Chloro-N-({4-[2-(cyanosulfamoyl)phenyl]phenyl}methyl)-N-[(4-methylphenyl)methyl]benzamide |
1019331-10-2 |
100mg |
￥285000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQJ-3550 |
2-Chloro-N-({4-[2-(cyanosulfamoyl)phenyl]phenyl}methyl)-N-[(4-methylphenyl)methyl]benzamide |
1019331-10-2 |
500mg |
￥855000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML0638 |
≥98% (HPLC)
S0859 ≥98% (HPLC) |
1019331-10-2 |
5mg |
￥22100 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML0638 |
≥98% (HPLC)
S0859 ≥98% (HPLC) |
1019331-10-2 |
25mg |
￥65800 |
2024-03-01 |
購入 |
S0859 化学特性,用途語,生産方法
説明
S0859 is an N-cyanosulphonamide that blocks the sodium/bicarbonate cotransporter (NBC, also known as SLC4A7), which regulates intracellular pH, particularly in myocytes. It inhibits intracellular pH recovery in myocytes with a K
i value of 1.7 μM, with full inhibition occurring at ~30 μM. S0859 does not affect other exchange proteins or enzymes that might regulate intracellular pH. It prevents changes in pH associated with depolarization and hyperpolarization of ventricular myocytes from rabbit, rat, and guinea pig. S0859 has also been used to study the role of NBC in coronary endothelial cells, cancer cells, embryonic kidney cells, and neutrophils.
使用
2-Chloro-N-[[2''-[(cyanoamino)sulfonyl][1,1''-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]benzamide is a selective inhibitor of sodium-bicarbonate cotransporters in mammalian heart.
Biochem/physiol Actions
S0859 is a selective high-affinity generic inhibitor of the Na+/HCO3- sodium bicarbonate co-transporter (NBC). S0859 does not inhibit Na+-H+ exchange (NHE).
S0859 上流と下流の製品情報
原材料
準備製品
S0859 生産企業
Global( 93)Suppliers
1019331-10-2()キーワード:
- 1019331-10-2
- 2-chloro-N-[[2'-[(cyanoamino)sulfonyl][1,1'-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]- S0859
- 2-Chloro-N-[[2′-[(cyanoamino)sulfonyl][1,1′-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]-benzamide
- 2-Chloro-N-((2'-(N-cyanosulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(4-methylbenzyl)benzamide
- S0859
- (4S)-4-HYDROXY-4-[(3R)-3-HYDROXYBUTYL]-3,5,5-TRIMETHYL-2-CYCLOHEXEN-1-ONE
- 100852
- S 0859; S-0859; S 0859; S-0859
- CS-1766
- S0859, >98%
- Benzamide, 2-chloro-N-[[2'-[(cyanoamino)sulfonyl][1,1'-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]-
- S0859 >=98% (HPLC)
- 2-Chloro-N-({4-[2-(cyanosulfamoyl)phenyl]phenyl}methyl)-N-[(4-methylphenyl)methyl]benzamide
- NBC(S0859)