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ギンクゴリドB

ギンクゴリドB 化学構造式
15291-77-7
CAS番号.
15291-77-7
化学名:
ギンクゴリドB
别名:
ギンクゴリドB;ギンコライドB;ギンコリドB;ギンコリドB GINKGO BILOBA(イチョウ)葉由来
英語化学名:
Ginkgolide B
英語别名:
BN 52021;BGinkgolid;GINKGOLIDE B;GINKGOLIDE B(SH);7-DEOXYGINKGOLIDE C;GINKOLIDE B;BN 52021;Ginkgolide B (BN-52021);GinkgolideA,1-hydroxy-, (1β)-;ginkgolide B from ginkgo leaves;Ginkgolide B, froM Ginkgo biloba
CBNumber:
CB3745566
化学式:
C20H24O10
分子量:
424.4
MOL File:
15291-77-7.mol

ギンクゴリドB 物理性質

融点 :
280°C (dec.)
比旋光度 :
D24 -52.6° (c = 1 in ethanol)
沸点 :
762.4±60.0 °C(Predicted)
比重(密度) :
1?+-.0.1 g/cm3(Predicted)
貯蔵温度 :
Sealed in dry,Store in freezer, under -20°C
外見 :
neat
酸解離定数(Pka):
pKa1 7.14; pKa2 8.60; pKa3 11.89(at 25℃)
水溶解度 :
Soluble in DMSO. Slightly soluble in water and ethanol
BRN :
4727611
InChIKey:
SQOJOAFXDQDRGF-MMQTXUMRSA-N
CAS データベース:
15291-77-7(CAS DataBase Reference)

安全性情報

Sフレーズ  24/25
WGK Germany  3
10-21
HSコード  29322090

ギンクゴリドB 価格 もっと(29)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00007181 ギンコリドB
GINKGOLIDE B
15291-77-7 10mg ¥59400 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00007181 ギンコリドB
GINKGOLIDE B
15291-77-7 5mg ¥11300 2020-09-21 購入
関東化学株式会社(KANTO) 49063-63 ギンクゴリドB
Ginkgolide B
15291-77-7 10mg ¥43000 2021-03-23 購入
Sigma-Aldrich Japan G6910 ギンコリドB Ginkgo biloba(イチョウ)葉由来 ≥90% (HPLC)
Ginkgolide B from Ginkgo biloba leaves ≥90% (HPLC)
15291-77-7 10mg ¥19300 2021-03-23 購入
Sigma-Aldrich Japan 94970 ギンコリドB analytical standard
Ginkgolide B analytical standard
15291-77-7 10mg ¥33800 2021-03-23 購入

ギンクゴリドB 化学特性,用途語,生産方法

外観

白色~ほとんど白色粉末~結晶

説明

Ginkgo biloba is a perennial tree belonging to Ginkgoaceae (Ginkgo biloba L., Yin Xing). Its seeds, also known as ginkgo, have a long history of application in traditional medicine for its medicinal value. With promoting blood circulation by removing blood stasis, Ginkgo biloba has a long history of its application in traditional Chinese medicine
In recent years, it has been widely used in the treatment of cerebral ischemic diseases. After further study, it was found that the effective component is ginkgolide compound, which laid the foundation for the development of small molecule drugs.

化学的特性

White Crystalline Solid

物理的性質

Appearance: ginkgolide B is a white powder. Solubility: weighed 0.98?g and dissolves in 1L water (calculation). Melting point: the compound melts at 280? °C (calculation)

来歴

The leaf of Ginkgo biloba is sweet, bitter, astringent, and mild. With activating blood circulation to remove blood stasis, dredging collaterals, relieving pain, and asthma, it is applied for treating blood stasis, chest pain, stroke, lung deficiency cough, and hyperlipidemia.
As early as in the 1930s, scientists began to study ginkgo and harvest a variety of ginkgolide . Ginkgolide B was isolated and its structure illustrated by Wan Shan et?al. in 1967. Subsequently, it was synthesized by Corey et?al. in 1988. The preparation of effective components of Ginkgo biloba has been listed at home and abroad with development.
The Ginkgo biloba extract consisting of ticlopidine is widely used in overseas market for the treatment of cerebral infarction. Intravenous injection of ginkgolide B is applied for the treatment of inflammation, but the project has been in the state, and there is no progress in it for many years. In addition, whether other extract of Ginkgo biloba can be used for the treatment of stable angina, cognitive impairment is still in preclinical research status.

使用

Ginkgo (Ginkgo biloba) Plant Profile: bioactives, mechanism of action, references

使用

Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists

使用

Ginkgolide B is used as a potent PAF-R antagonist. Ginkgolide B speeds up PAF hydrolysis by promoting PAF-AH I α2 homodimer activity. Additionally, this compound has been reported to inhibit neutrophil degranulation in vitro. Inhibits superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo.

適応症

The injection consists of multiple components, and there are three kinds of substance mainly in diterpene ginkgolides meglumine injection. It promotes blood circulation by removing blood stasis and activates the channels and collaterals for cerebral ischemia treatment.

生物活性

Platelet-activating factor (PAF) receptor antagonist (K i = 1.3 μ M). Inhibits neutrophil degranulation and superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo .

薬理学

Ginkgolide B has a variety of pharmacological effects, mainly in cardiovascular and cerebrovascular protection and neuroprotection. On the one hand, with the strongest activity in nature, the platelet-activating factor (PAF) receptor antagonist is recognized by the public . PAF can inhibit the downstream inflammatory cascade for anti-inflammatory. It also can alleviate cerebral infraction volume and cerebral edema induced by cerebral ischemia among the animal model of cerebral ischemia reperfusion through unknown mechanism. By inhibiting NF-κB and TNF-α, the apoptosis of nerve cell can be alleviated. The compound protects the abdominal cavity and intestinal tract by inhibiting release of neutrophil chemotactic protein by macrophage.

臨床応用

Oral and injection preparations are applied widely in clinical therapy. Made in oral preparation, flavonoids are the main component of raw material. There are little chemical compounds in injection, and ginkgolides are the main component whose content is different from each other. Listed ginkgolide injection is applied for ischemia stroke formed by blood stasis with promoting blood circulation by removing blood stasis and clearing and activating the channels and collaterals. Compared with Shuxuening injection in clinical trials, ginkgolides injection is consistent in improving indicators effect, such as protection in nerve injury and others.

ギンクゴリドB 上流と下流の製品情報

原材料

準備製品


ギンクゴリドB 生産企業

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15291-77-7(ギンクゴリドB)キーワード:


  • 15291-77-7
  • BN 52021
  • GINKGOLIDE B
  • ginkgolide B from ginkgo leaves
  • (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
  • ginkgolide b from ginkgo biloba leaves
  • GinkgolideA,1-hydroxy-, (1β)-
  • Ginkgolide B, froM Ginkgo biloba
  • BGinkgolid
  • GINKGOLIDE B(SH)
  • 7-DEOXYGINKGOLIDE C
  • Ginkgolide B, 98%, from Ginkgo biloba L.
  • GINKOLIDE B;BN 52021
  • Ginkgolide B (BN-52021)
  • ギンクゴリドB
  • ギンコライドB
  • ギンコリドB
  • ギンコリドB GINKGO BILOBA(イチョウ)葉由来
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