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Ginkgolide B Produkt Beschreibung

Ginkgolide B Struktur
Englisch Name:
Ginkgolide B
BN 52021;BGinkgolid;GINKGOLIDE B;GINKGOLIDE B(SH);7-DEOXYGINKGOLIDE C;GINKOLIDE B;BN 52021;GinkgolideA,1-hydroxy-, (1β)-;ginkgolide B from ginkgo leaves;Ginkgolide B, froM Ginkgo biloba;ginkgolide b from ginkgo biloba leaves

Ginkgolide B Eigenschaften

280°C (dec.)
D24 -52.6° (c = 1 in ethanol)
762.4±60.0 °C(Predicted)
1?+-.0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
pKa1 7.14; pKa2 8.60; pKa3 11.89(at 25℃)
Soluble in DMSO. Slightly soluble in water and ethanol
CAS Datenbank
15291-77-7(CAS DataBase Reference)


S-Sätze: 24/25
WGK Germany  3
HS Code  29322090

Ginkgolide B Chemische Eigenschaften,Einsatz,Produktion Methoden


Ginkgo biloba is a perennial tree belonging to Ginkgoaceae (Ginkgo biloba L., Yin Xing). Its seeds, also known as ginkgo, have a long history of application in traditional medicine for its medicinal value. With promoting blood circulation by removing blood stasis, Ginkgo biloba has a long history of its application in traditional Chinese medicine
In recent years, it has been widely used in the treatment of cerebral ischemic diseases. After further study, it was found that the effective component is ginkgolide compound, which laid the foundation for the development of small molecule drugs.

Chemische Eigenschaften

White Crystalline Solid

Physikalische Eigenschaften

Appearance: ginkgolide B is a white powder. Solubility: weighed 0.98?g and dissolves in 1L water (calculation). Melting point: the compound melts at 280? °C (calculation)


The leaf of Ginkgo biloba is sweet, bitter, astringent, and mild. With activating blood circulation to remove blood stasis, dredging collaterals, relieving pain, and asthma, it is applied for treating blood stasis, chest pain, stroke, lung deficiency cough, and hyperlipidemia.
As early as in the 1930s, scientists began to study ginkgo and harvest a variety of ginkgolide . Ginkgolide B was isolated and its structure illustrated by Wan Shan et?al. in 1967. Subsequently, it was synthesized by Corey et?al. in 1988. The preparation of effective components of Ginkgo biloba has been listed at home and abroad with development.
The Ginkgo biloba extract consisting of ticlopidine is widely used in overseas market for the treatment of cerebral infarction. Intravenous injection of ginkgolide B is applied for the treatment of inflammation, but the project has been in the state, and there is no progress in it for many years. In addition, whether other extract of Ginkgo biloba can be used for the treatment of stable angina, cognitive impairment is still in preclinical research status.


Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists


Ginkgo (Ginkgo biloba) Plant Profile: bioactives, mechanism of action, references


The injection consists of multiple components, and there are three kinds of substance mainly in diterpene ginkgolides meglumine injection. It promotes blood circulation by removing blood stasis and activates the channels and collaterals for cerebral ischemia treatment.

Biologische Aktivität

Platelet-activating factor (PAF) receptor antagonist (K i = 1.3 μ M). Inhibits neutrophil degranulation and superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo .


Ginkgolide B has a variety of pharmacological effects, mainly in cardiovascular and cerebrovascular protection and neuroprotection. On the one hand, with the strongest activity in nature, the platelet-activating factor (PAF) receptor antagonist is recognized by the public . PAF can inhibit the downstream inflammatory cascade for anti-inflammatory. It also can alleviate cerebral infraction volume and cerebral edema induced by cerebral ischemia among the animal model of cerebral ischemia reperfusion through unknown mechanism. By inhibiting NF-κB and TNF-α, the apoptosis of nerve cell can be alleviated. The compound protects the abdominal cavity and intestinal tract by inhibiting release of neutrophil chemotactic protein by macrophage.

Clinical Use

Oral and injection preparations are applied widely in clinical therapy. Made in oral preparation, flavonoids are the main component of raw material. There are little chemical compounds in injection, and ginkgolides are the main component whose content is different from each other. Listed ginkgolide injection is applied for ischemia stroke formed by blood stasis with promoting blood circulation by removing blood stasis and clearing and activating the channels and collaterals. Compared with Shuxuening injection in clinical trials, ginkgolides injection is consistent in improving indicators effect, such as protection in nerve injury and others.

Ginkgolide B Upstream-Materialien And Downstream Produkte


Downstream Produkte

Ginkgolide B Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 267)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 29961 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897 CHINA 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768 CHINA 2972 58
Chongqing Chemdad Co.,Ltd
+86-19923101450 CHINA 4000 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23035 58
BOC Sciences
1-631-614-7828 United States 19753 58
Chongqing Chemdad Co., Ltd
+86-13650506873 CHINA 37282 58

15291-77-7()Verwandte Suche:

  • BN 52021
  • ginkgolide B from ginkgo leaves
  • (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
  • ginkgolide b from ginkgo biloba leaves
  • GinkgolideA,1-hydroxy-, (1β)-
  • Ginkgolide B, froM Ginkgo biloba
  • BGinkgolid
  • Ginkgolide B, 98%, from Ginkgo biloba L.
  • GINKOLIDE B;BN 52021
  • 15291-77-7
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