ピラゾラム

ピラゾラム 化学構造式
39243-02-2
CAS番号.
39243-02-2
化学名:
ピラゾラム
别名:
12-ブロモ-3-メチル-9-(ピリジン-2-イル)-2,4,5,8-テトラアザトリシクロ[8.4.0.02,6]テトラデカ-1(14),3,5,8,10,12-ヘキサエン;ピラゾラム;8-ブロモ-1-メチル-6-(2-ピリジニル)-4H-[1,2,4]トリアゾロ[4,3-a][1,4]ベンゾジアゼピン
英語名:
Pyrazolam
英語别名:
Amuchin;formaty;Pirazolam;Pyrazolam;Pyrazolam 1;Pyrazolam solution;ANTIOXIDANT PUB-380;PU sealing ring PU O-ring;GE IS200TREGH1BDB Triple DCS/SIS module;NI SCXI-1193 RF multiplexer switch module
CBNumber:
CB42742476
化学式:
C16H12BrN5
分子量:
354.2
MOL File:
39243-02-2.mol

ピラゾラム 物理性質

融点 :
253-255 °C
沸点 :
544.4±60.0 °C(Predicted)
比重(密度) :
1.62±0.1 g/cm3(Predicted)
貯蔵温度 :
-20°C
溶解性:
DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml; Methanol: 1 mg/ml
外見 :
A crystalline solid
酸解離定数(Pka):
2.18±0.40(Predicted)
InChI:
InChI=1S/C16H12BrN5/c1-10-20-21-15-9-19-16(13-4-2-3-7-18-13)12-8-11(17)5-6-14(12)22(10)15/h2-8H,9H2,1H3
InChIKey:
BGRWSFIQQPVEML-UHFFFAOYSA-N
SMILES:
N12C(C)=NN=C1CN=C(C1=NC=CC=C1)C1=CC(Br)=CC=C12
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
RIDADR  UN 1648 3 / PGII
絵表示(GHS) GHS hazard pictograms
注意喚起語
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告 GHS hazard pictograms
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P271 屋外または換気の良い場所でのみ使用すること。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P302+P352 皮膚に付着した場合:多量の水と石鹸で洗うこと。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P312 気分が悪い時は医師に連絡すること。
P321 特別な処置が必要である(このラベルの... を見よ)。
P332+P313 皮膚刺激が生じた場合:医師の診断/手当てを受けるこ と。
P337+P313 眼の刺激が続く場合:医師の診断/手当てを受けること。

ピラゾラム 化学特性,用途語,生産方法

説明

Pyrazolam (SH-I-04) is a benzodiazepine derivative originally developed by a team led by Leo Sternbach at Hoffman-La Roche in the 1970s. It has since been "rediscovered" and sold as a designer drug since 2012.
Pyrazolam has structural similarities to alprazolam and bromazepam. Unlike other benzodiazepines, pyrazolam does not appear to undergo metabolism, instead being excreted unchanged in the urine. It is most selective for the α2 and α3 subtypes of the GABAA receptor.

化学的特性

Pyrazolam is a benzodiazepine that has been abused recreationally. Like other benzodiazepines, pyrazolam has anxiolytic effects.

使用

Pyrazolam is a benzodiazepine with an elimination half-life of about 17 hours and no detectable metabolites in human serum and urine; thus pyrazolam may go undetected without instrumental analytical techniques.

主な応用

Pyrazolam is a designer benzodiazepine that has been sold online as a 'legal high' or 'research chemical'. Since its emergence in Europe a few years ago, pyrazolam, along with other designer benzodiazepines, have increasingly been encountered in forensic case work.

生物活性

Pyrazolam has structural similarities to alprazolam and bromazepam. Unlike other benzodiazepines, pyrazolam does not appear to undergo metabolism, instead being excreted unchanged in the urine.It is most selective for the α2 and α3 subtypes of the GABAA receptor.

薬理学

Benzodiazepines produce a variety of effects by binding to the benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this site is the most prolific inhibitory receptor set within the brain, its modulation results in the sedating (or calming effects) of pyrazolam on the nervous system.The anticonvulsant properties of benzodiazepines may be, in part or entirely, due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors.Pyrazolam is most selective for the α2 and α3 receptor subtypes. It is excreted by the body unchanged thus not interacting with liver enzymes like other benzodiazepines, meaning that its use in people with reduced liver function may be safer.

ピラゾラム 上流と下流の製品情報

原材料

準備製品

39243-02-2(ピラゾラム)キーワード:


  • 39243-02-2
  • Pyrazolam
  • 8-Bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine
  • formaty
  • Pyrazolam solution
  • 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-bromo-1-methyl-6-(2-pyridinyl)-
  • 8-Bromo-1-methyl-6-(2-pyridinyl)-4H-[1,2,4]triazolo[4,3-a][1,4]be nzodiazepine
  • ANTIOXIDANT PUB-380
  • Pyrazolam 1
  • Amuchin
  • 8-BROMO-1-METHYL-6-(PYRIDIN-2-YL)-4H-BENZO[F][1,2,4]TRIAZOLO[4,3-A][1,4]D+
  • Pirazolam
  • PU sealing ring PU O-ring
  • High Temperature High Pressure Corrosion Resistance Abrasion Resistance O Ring VITON Low Temperature GLT Fluoro Rubber O Ring FKM Sealing Ring
  • Corrosion resistant high pressure resistant PTFE FEP coated sealing ring
  • VITON Low Temperature Resistant GLT Fluoro Rubber O-ring FKM Sealing Ring O-ring
  • PFA Silica Gel SIL Fluorine Adhesive VITON Sealing Ring PTFE Cladding Ring
  • Fluorosilicone O-ring FDA Food Grade Certification SIL Silicone Sealing Ring
  • FDA Food Grade O Ring HNBR Hydrogenated Acrylic Rubber Sealing Ring
  • Custom FDA Food Grade FKM Fluorine Glue O-type Sealing Ring
  • GE IS220PDIOH1B 336A5026ADP6 Gas turbine control module
  • GE IS200TREGH1BDB Triple DCS/SIS module
  • EMERSON VE3008 CE3008 KJ2005X1-MQ1 12P6381X032 Fieldbus controller
  • ABB PCD530A102 3BHE041343R0102 Distributed Control System Module
  • NI SCXI-1193 RF multiplexer switch module
  • ABB PCD230A 3BHE022291R0101 Communication input/output module
  • 12-ブロモ-3-メチル-9-(ピリジン-2-イル)-2,4,5,8-テトラアザトリシクロ[8.4.0.02,6]テトラデカ-1(14),3,5,8,10,12-ヘキサエン
  • ピラゾラム
  • 8-ブロモ-1-メチル-6-(2-ピリジニル)-4H-[1,2,4]トリアゾロ[4,3-a][1,4]ベンゾジアゼピン
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