Pyrazolam

Pyrazolam Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Pyrazolam (SH-I-04) is a benzodiazepine derivative originally developed by a team led by Leo Sternbach at Hoffman-La Roche in the 1970s. It has since been "rediscovered" and sold as a designer drug since 2012.
Pyrazolam has structural similarities to alprazolam and bromazepam. Unlike other benzodiazepines, pyrazolam does not appear to undergo metabolism, instead being excreted unchanged in the urine. It is most selective for the α2 and α3 subtypes of the GABAA receptor.

Chemische Eigenschaften

Pyrazolam is a benzodiazepine that has been abused recreationally. Like other benzodiazepines, pyrazolam has anxiolytic effects.

Verwenden

Pyrazolam is a benzodiazepine with an elimination half-life of about 17 hours and no detectable metabolites in human serum and urine; thus pyrazolam may go undetected without instrumental analytical techniques.

Application

Pyrazolam is a designer benzodiazepine that has been sold online as a 'legal high' or 'research chemical'. Since its emergence in Europe a few years ago, pyrazolam, along with other designer benzodiazepines, have increasingly been encountered in forensic case work.

Biologische Aktivität

Pyrazolam has structural similarities to alprazolam and bromazepam. Unlike other benzodiazepines, pyrazolam does not appear to undergo metabolism, instead being excreted unchanged in the urine.It is most selective for the α2 and α3 subtypes of the GABAA receptor.

Pharmakologie

Benzodiazepines produce a variety of effects by binding to the benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this site is the most prolific inhibitory receptor set within the brain, its modulation results in the sedating (or calming effects) of pyrazolam on the nervous system.The anticonvulsant properties of benzodiazepines may be, in part or entirely, due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors.Pyrazolam is most selective for the α2 and α3 receptor subtypes. It is excreted by the body unchanged thus not interacting with liver enzymes like other benzodiazepines, meaning that its use in people with reduced liver function may be safer.

Pyrazolam Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

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• Pyrazolam
• 8-Bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine
• formaty
• Pyrazolam solution
• 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-bromo-1-methyl-6-(2-pyridinyl)-
• 8-Bromo-1-methyl-6-(2-pyridinyl)-4H-[1,2,4]triazolo[4,3-a][1,4]be nzodiazepine
• ANTIOXIDANT PUB-380
• Pyrazolam 1
• Amuchin
• 8-BROMO-1-METHYL-6-(PYRIDIN-2-YL)-4H-BENZO[F][1,2,4]TRIAZOLO[4,3-A][1,4]D+
• Pirazolam
• PU sealing ring PU O-ring
• High Temperature High Pressure Corrosion Resistance Abrasion Resistance O Ring VITON Low Temperature GLT Fluoro Rubber O Ring FKM Sealing Ring
• Corrosion resistant high pressure resistant PTFE FEP coated sealing ring
• VITON Low Temperature Resistant GLT Fluoro Rubber O-ring FKM Sealing Ring O-ring
• PFA Silica Gel SIL Fluorine Adhesive VITON Sealing Ring PTFE Cladding Ring
• Fluorosilicone O-ring FDA Food Grade Certification SIL Silicone Sealing Ring
• FDA Food Grade O Ring HNBR Hydrogenated Acrylic Rubber Sealing Ring
• Custom FDA Food Grade FKM Fluorine Glue O-type Sealing Ring
• GE IS220PDIOH1B 336A5026ADP6 Gas turbine control module
• GE IS200TREGH1BDB Triple DCS/SIS module
• EMERSON VE3008 CE3008 KJ2005X1-MQ1 12P6381X032 Fieldbus controller
• ABB PCD530A102 3BHE041343R0102 Distributed Control System Module
• NI SCXI-1193 RF multiplexer switch module
• ABB PCD230A 3BHE022291R0101 Communication input/output module
• 39243-02-2
• 500-00-1
• 500-00-2
• Pyrazolam
• 39243-02-2