2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
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- CAS番号.
- 91591-63-8
- 化学名:
- 别名:
- 英語名:
- 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
- 英語别名:
- 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE;3-Cyano-2,5-dichloro-4,6-dimethylpyridine;2,5-Dichloro-4,6-dimethylnicotinonitrile 95+%;2,5-DICHLORO-4,6-DIMETHYLPYRIDINE-3-CARBONITRILE;2,5-Dichloro-4,6-diMethyl-3-pyridinecarbonitrile;3-Pyridinecarbonitrile,2,5-dichloro-4,6-dimethyl-;2,5-Dichloro-4,6-dimethylpyridine-3-carbonitrile, 3-Cyano-2,5-dichloro-4,6-dimethylpyridine
- CBNumber:
- CB5352041
- 化学式:
- C8H6Cl2N2
- 分子量:
- 201.05
- MOL File:
- 91591-63-8.mol
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2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE 物理性質
- 融点 :
- 82 °C
- 沸点 :
- 304.6±37.0 °C(Predicted)
- 比重(密度) :
- 1.36
- 貯蔵温度 :
- under inert gas (nitrogen or Argon) at 2-8°C
- 外見 :
- solid
- 酸解離定数(Pka):
- -2.79±0.10(Predicted)
- 色:
- White
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
絵表示(GHS) |
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注意喚起語 |
警告 |
危険有害性情報 |
コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
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P264, P270, P301+P312, P330, P501 |
H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
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P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
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P264, P280, P305+P351+P338,P337+P313P |
H335 |
呼吸器への刺激のおそれ |
特定標的臓器毒性、単回暴露; 気道刺激性 |
3 |
警告 |
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注意書き |
P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
P305+P351+P338 |
眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
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2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE 価格
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE 化学特性,用途語,生産方法
使用
2,5-Dichloro-4,6-dimethyl-3-pyridinecarbonitrile, can be used for the synthesis of a selective muscarinic receptor 4 (M4) positive allosteric modulator called ML253, which is a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.
合成
Phosphoryl chloride (973.2g), tetramethylammonium chloride (67.3g) and compound of Preparation 2 (227.1g) were added to dichloromethane (500g). The suspension was heated to 85°C and stirred for 5 hours. Excess of phosphoryl chloride was removed by distillation in vacuo. The reaction mixture was cooled below 30 °C and diluted with dichloromethane. The resulting solution was added to water (1350g) at room temperature and stirred for 30 minutes. The lower organic phase was separate and the aqueous phase extracted with dichloromethane. The organic phases were combined, washed with water and then treated with charcoal. The charcoal was filtered and a solvent swap to heptane was performed by distillation at atmospheric pressure. The solution was filtered at 50 °C and then cooled to 30 °C. On further cooling to 0°C crystals were obtained. These were isolated by filtration, washed twice with heptane. After drying at 50°C the desired product was obtained typically at 88-91 % . The above process was repeated with a reduction in dichloromethane during crystallisation and adding some methanol. The resulting plate-like crystals were more easily transferred for subsequent use.
2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE 上流と下流の製品情報
原材料
準備製品
2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE 生産企業
Global( 163)Suppliers
91591-63-8()キーワード:
- 91591-63-8
- 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
- 2,5-DICHLORO-4,6-DIMETHYLPYRIDINE-3-CARBONITRILE
- 2,5-Dichloro-4,6-dimethylpyridine-3-carbonitrile, 3-Cyano-2,5-dichloro-4,6-dimethylpyridine
- 2,5-Dichloro-4,6-diMethyl-3-pyridinecarbonitrile
- 3-Cyano-2,5-dichloro-4,6-dimethylpyridine
- 2,5-Dichloro-4,6-dimethylnicotinonitrile 95+%
- 3-Pyridinecarbonitrile,2,5-dichloro-4,6-dimethyl-