2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
- CAS No.
- 91591-63-8
- Chemical Name:
- 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
- Synonyms
- 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE;3-Cyano-2,5-dichloro-4,6-dimethylpyridine;2,5-Dichloro-4,6-dimethylnicotinonitrile 95+%;2,5-DICHLORO-4,6-DIMETHYLPYRIDINE-3-CARBONITRILE;2,5-Dichloro-4,6-diMethyl-3-pyridinecarbonitrile;3-Pyridinecarbonitrile,2,5-dichloro-4,6-dimethyl-;2,5-Dichloro-4,6-dimethylpyridine-3-carbonitrile, 3-Cyano-2,5-dichloro-4,6-dimethylpyridine
- CBNumber:
- CB5352041
- Molecular Formula:
- C8H6Cl2N2
- Molecular Weight:
- 201.05
- MDL Number:
- MFCD00052631
- MOL File:
- 91591-63-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36/37/39 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D434275 | 2,5-Dichloro-4,6-dimethyl-3-pyridinecarbonitrile | 91591-63-8 | 10g | $415 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD04336 | 2,5-Dichloro-4,6-dimethylnicotinonitrile | 91591-63-8 | 25g | $500 | 2021-12-16 | Buy |
| AK Scientific | W9486 | 2,5-Dichloro-4,6-dimethylnicotinonitrile | 91591-63-8 | 100g | $531 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0017821 | 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE 95.00% | 91591-63-8 | 1G | $649.11 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0017821 | 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE 95.00% | 91591-63-8 | 10G | $1471.47 | 2021-12-16 | Buy |
2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE Chemical Properties,Uses,Production
Uses
2,5-Dichloro-4,6-dimethyl-3-pyridinecarbonitrile, can be used for the synthesis of a selective muscarinic receptor 4 (M4) positive allosteric modulator called ML253, which is a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.
Synthesis
Phosphoryl chloride (973.2g), tetramethylammonium chloride (67.3g) and compound of Preparation 2 (227.1g) were added to dichloromethane (500g). The suspension was heated to 85°C and stirred for 5 hours. Excess of phosphoryl chloride was removed by distillation in vacuo. The reaction mixture was cooled below 30 °C and diluted with dichloromethane. The resulting solution was added to water (1350g) at room temperature and stirred for 30 minutes. The lower organic phase was separate and the aqueous phase extracted with dichloromethane. The organic phases were combined, washed with water and then treated with charcoal. The charcoal was filtered and a solvent swap to heptane was performed by distillation at atmospheric pressure. The solution was filtered at 50 °C and then cooled to 30 °C. On further cooling to 0°C crystals were obtained. These were isolated by filtration, washed twice with heptane. After drying at 50°C the desired product was obtained typically at 88-91 % . The above process was repeated with a reduction in dichloromethane during crystallisation and adding some methanol. The resulting plate-like crystals were more easily transferred for subsequent use.
2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753; +8613336034509 | sales@fluoropharm.com | China | 1290 | 60 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4242 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 7838 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | ,+86-21-56795779; +8613651600618 | sales@worldyachem.com | China | 879 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2169 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
| Changzhou Carman Chemical Co., Ltd. | 15061933924 | CHINA | 514 | 58 |
View Lastest Price from 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-05-09 | 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
91591-63-8
|
US $0.00 / kg | 1kg | 98% | 2000kg | Chongqing Chemdad Co., Ltd | |
 |
2022-10-14 | 2,5-Dichloro-4,6-dimethylnicotinonitrile
91591-63-8
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2021-12-21 | 2,5-Dichloro-4,6-Dimethylnicotinonitrile
91591-63-8
|
US $10.00 / KG | 1KG | ≥98% | 100tons | Qiuxian Baitai New Material Co., LTD |
-
- 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
91591-63-8
- US $0.00 / kg
- 98%
- Chongqing Chemdad Co., Ltd
-
- 2,5-Dichloro-4,6-dimethylnicotinonitrile
91591-63-8
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2,5-Dichloro-4,6-Dimethylnicotinonitrile
91591-63-8
- US $10.00 / KG
- ≥98%
- Qiuxian Baitai New Material Co., LTD
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