Chinese english Germany Korea

Pomalidomide-PEG4-CO2H

化学構造式
2138440-81-8
CAS番号.
2138440-81-8
化学名:
别名:
英語名:
Pomalidomide-PEG4-CO2H
英語别名:
Pomalidomide-PEG4-COOH;Poma-PEG4-COOH;Pomalidomide-PEG4-CO2H;POMALIDOMIDE-PEG4-CO 2 H;Pomalidomide 4'-PEG4-acid;Thalidomide-NH-PEG4-C2-COOH;1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxapentadecan-15-oic Acid;1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid;Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-;1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
CBNumber:
CB54846410
化学式:
C24H31N3O10
分子量:
521.52
MOL File:
2138440-81-8.mol
MSDS File:
SDS

Pomalidomide-PEG4-CO2H 物理性質

沸点 :
773.6±60.0 °C(Predicted)
比重(密度) :
1.385±0.06 g/cm3(Predicted)
貯蔵温度 :
2-8°C
酸解離定数(Pka):
4.28±0.10(Predicted)

安全性情報

Pomalidomide-PEG4-CO2H 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan 901824
Pomalidomide-PEG4-CO2H 		2138440-81-8 50MG ￥75900 2024-03-01 購入

Pomalidomide-PEG4-CO2H 化学特性,用途語,生産方法

使用

Protein degrader builiding block Pomalidomide-PEG4-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition and E3 ligase ligand.

Pomalidomide-PEG4-CO2H 上流と下流の製品情報

原材料

準備製品

Pomalidomide-PEG4-CO2H 生産企業

Global( 23)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43348 58
Xian confluore Biological Technology Co., Ltd. 		+86-15680926068 +86-15680926068
 1924344760@confluore.cn China 2893 58
Aladdin Scientific 		+1-833-552-7181
sales@aladdinsci.com United States 57511 58
ChemShuttle, Inc. 0510-83588313-802 18800520310;
 sales@chemshuttle.com China 3062 62
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51471 80
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136
 info@SuperLan-chem.com China 9445 58
Aikon International Limited 025-58851090 13611564524
 lwan@aikonchem.com China 15952 58
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068
 1924344760@qq.com China 4955 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624
 1927928688@qq.com China 1292 58
DC Chemicals 021-58447131 13564518121
 sales@dcchemicals.com China 9414 58
  • 2138440-81-8
  • POMALIDOMIDE-PEG4-CO 2 H
  • Pomalidomide-PEG4-CO2H
  • 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid
  • Pomalidomide-PEG4-COOH
  • Thalidomide-NH-PEG4-C2-COOH
  • Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-
  • 1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxapentadecan-15-oic Acid
  • 1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
  • Poma-PEG4-COOH
  • Pomalidomide 4'-PEG4-acid
Copyright 2017 © ChemicalBook. All rights reserved