1-ニトロソ-2-(3-ピリジニル)ピロリジン 化学特性,用途語,生産方法
説明
A nicotine alkaloid, this base has been detected in some Japanese cigarette tobaccos and also in Kirsu tobacco where it occurs in the fresh leaves that have been dried without fermentation. From these two sources it has been isolated at 1.1 and 1. 8 ppm levels respectively
化学的特性
white crystals
使用
A tobacco alkaloid as risk factor of human cancer.
一般的な説明
White crystalline flakes or yellow oil that solidifies on standing in the cold.
空気と水の反応
Insoluble in water.
反応プロフィール
A nitrated amine, nicotine derivative. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
健康ハザード
ACUTE/CHRONIC HAZARDS: When heated to decomposition it may emit toxic and hazardous fumes of NOx and COx.
火災危険
Flash point data for N'-NITROSONORNICOTINE are not available; however, N'-NITROSONORNICOTINE is probably combustible.
安全性プロファイル
Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, and tumorigenic data. Low
toxicity by intraperitoneal route. Mutation
data reported. When heated to
decomposition it emits toxic fumes of NOx.
See also N-NITROSO COMPOUNDS.
発がん性
N-Nitrosonornicotine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
参考文献
Bharadwaj et al., Gann., 66, 585 (1975)
1-ニトロソ-2-(3-ピリジニル)ピロリジン 上流と下流の製品情報
原材料
準備製品